National Eye Institute Publications ( 80 ) Zagon IS. Sassani JW. Myers RL. McLaughlin PJ. Naltrexone accelerates healing without compromise of adhesion complexes in normal and diabetic corneal epithelium. 2007 Apr 2. Brain Res Bull. 72(1):18-24. National Eye Institute Klocek MS. Sassani JW. McLaughlin PJ. Zagon IS. Topically applied naltrexone restores corneal reepithelialization in diabetic rats. 2007 Apr. J Ocul Pharmacol Ther. 23(2):89-102. National Eye Institute Xu Y. Ola MS. Berkich DA. Gardner TW. Barber AJ. Palmieri F. Hutson SM. LaNoue KF. Energy sources for glutamate neurotransmission in the retina: absence of the aspartate/glutamate carrier produces reliance on glycolysis in glia. 2007 Apr. J Neurochem. 101(1):120-31. National Eye Institute National Institute of Neurological Disorders and Stroke Erickson KK. Sundstrom JM. Antonetti DA. Vascular permeability in ocular disease and the role of tight junctions. 2007. Angiogenesis. 10(2):103-17. National Eye Institute Antonetti DA. Barber AJ. Bronson SK. Freeman WM. Gardner TW. Jefferson LS. Kester M. Kimball SR. Krady JK. LaNoue KF. Norbury CC. Quinn PG. Sandirasegarane L. Simpson IA. JDRF Diabetic Retinopathy Center Group. Diabetic retinopathy: seeing beyond glucose-induced microvascular disease. 2006 Sep. Diabetes. 55(9):2401-11. National Eye Institute Zagon IS. Klocek MS. Sassani JW. Mauger DT. McLaughlin PJ. Corneal safety of topically applied naltrexone. 2006 Oct. J Ocul Pharmacol Ther. 22(5):377-87. National Eye Institute Gregori NZ. Rosenfeld PJ. Puliafito CA. Flynn HW. Lee JE. Mavrofrides EC. Smiddy WE. Murray TG. Berrocal AM. Scott IU. Gregori G. One-year safety and efficacy of intravitreal triamcinolone acetonide for the management of macular edema secondary to central retinal vein occlusion. 2006 Oct. Retina. 26(8):889-95. National Eye Institute Zagon IS. Sassani JW. Malefyt KJ. McLaughlin PJ. Regulation of corneal repair by particle-mediated gene transfer of opioid growth factor receptor complementary DNA. 2006 Nov. Arch Ophthalmol. 124(11):1620-4. National Eye Institute Harhaj NS. Felinski EA. Wolpert EB. Sundstrom JM. Gardner TW. Antonetti DA. VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability. 2006 Nov. Invest Ophthalmol Vis Sci. 47(11):5106-15. National Eye Institute Maines LW. French KJ. Wolpert EB. Antonetti DA. Smith CD. Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases. 2006 Nov. Invest Ophthalmol Vis Sci. 47(11):5022-31. National Eye Institute Fox TE. Han X. Kelly S. Merrill AH. Martin RE. Anderson RE. Gardner TW. Kester M. Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathy. 2006 Dec. Diabetes. 55(12):3573-80. National Institute on Aging National Eye Institute National Center for Research Resources Zagon IS. Sassani JW. McLaughlin PJ. Adaptation of homeostatic ocular surface epithelium to chronic treatment with the opioid antagonist naltrexone. 2006 Aug. Cornea. 25(7):821-9. National Eye Institute Reiter CE. Wu X. Sandirasegarane L. Nakamura M. Gilbert KA. Singh RS. Fort PE. Antonetti DA. Gardner TW. Diabetes reduces basal retinal insulin receptor signaling: reversal with systemic and local insulin. 2006 Apr. Diabetes. 55(4):1148-56. National Eye Institute National Institute of General Medical Sciences Zagon IS. Sassani JW. McLaughlin PJ. Insulin treatment ameliorates impaired corneal reepithelialization in diabetic rats. 2006 Apr. Diabetes. 55(4):1141-7. National Eye Institute Maines LW. Antonetti DA. Wolpert EB. Smith CD. Evaluation of the role of P-glycoprotein in the uptake of paroxetine, clozapine, phenytoin and carbamazapine by bovine retinal endothelial cells. 2005 Oct. Neuropharmacology. 49(5):610-7. National Eye Institute Barber AJ. Antonetti DA. Kern TS. Reiter CE. Soans RS. Krady JK. Levison SW. Gardner TW. Bronson SK. The Ins2Akita mouse as a model of early retinal complications in diabetes. 2005 Jun. Invest Ophthalmol Vis Sci. 46(6):2210-8. National Eye Institute Zagon IS. Sassani JW. Verderame MF. McLaughlin PJ. Particle-mediated gene transfer of opioid growth factor receptor cDNA regulates cell proliferation of the corneal epithelium. 2005 Jul. Cornea. 24(5):614-9. National Eye Institute Zhang SS. Liu MG. Kano A. Zhang C. Fu XY. Barnstable CJ. STAT3 activation in response to growth factors or cytokines participates in retina precursor proliferation. 2005 Jul. Exp Eye Res. 81(1):103-15. National Eye Institute Lamason RL. Mohideen MA. Mest JR. Wong AC. Norton HL. Aros MC. Jurynec MJ. Mao X. Humphreville VR. Humbert JE. Sinha S. Moore JL. Jagadeeswaran P. Zhao W. Ning G. Makalowska I. McKeigue PM. O'donnell D. Kittles R. Parra EJ. Mangini NJ. Grunwald DJ. Shriver MD. Canfield VA. Cheng KC. SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans. 2005 Dec 16. Science. 310(5755):1782-6. National Cancer Institute National Eye Institute National Institute of Child Health and Human Development National Human Genome Research Institute National Heart, Lung, and Blood Institute National Center for Research Resources Tombran-Tink J. Aparicio S. Xu X. Tink AR. Lara N. Sawant S. Barnstable CJ. Zhang SS. PEDF and the serpins: phylogeny, sequence conservation, and functional domains. 2005 Aug. J Struct Biol. 151(2):130-50. National Eye Institute Klein RJ. Zeiss C. Chew EY. Tsai JY. Sackler RS. Haynes C. Henning AK. SanGiovanni JP. Mane SM. Mayne ST. Bracken MB. Ferris FL. Ott J. Barnstable C. Hoh J. Complement factor H polymorphism in age-related macular degeneration. 2005 Apr 15. Science. 308(5720):385-9. National Center for Research Resources National Human Genome Research Institute National Eye Institute National Institute of Mental Health Zhang SS. Xu X. Li J. Liu MG. Zhao H. Soares MB. Barnstable CJ. Fu XY. Comprehensive in silico functional specification of mouse retina transcripts. 2005. BMC Genomics. 6(1):40. National Eye Institute Wu X. Reiter CE. Antonetti DA. Kimball SR. Jefferson LS. Gardner TW. Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner. 2004 Mar 5. J Biol Chem. 279(10):9167-75. National Institute of Diabetes and Digestive and Kidney Diseases National Eye Institute Zhang SS. Wei J. Qin H. Zhang L. Xie B. Hui P. Deisseroth A. Barnstable CJ. Fu XY. STAT3-mediated signaling in the determination of rod photoreceptor cell fate in mouse retina. 2004 Jul. Invest Ophthalmol Vis Sci. 45(7):2407-12. National Eye Institute DeMaio L. Tarbell JM. Scaduto RC. Gardner TW. Antonetti DA. A transmural pressure gradient induces mechanical and biological adaptive responses in endothelial cells. 2004 Feb. Am J Physiol Heart Circ Physiol. 286(2):H731-41. National Eye Institute National Heart, Lung, and Blood Institute Liao D. Wong TY. Klein R. Jones D. Hubbard L. Sharrett AR. Relationship between carotid artery stiffness and retinal arteriolar narrowing in healthy middle-aged persons. 2004 Apr. Stroke. 35(4):837-42. National Eye Institute National Heart, Lung, and Blood Institute Zagon IS. Ruth TB. Leure-duPree AE. Sassani JW. McLaughlin PJ. Immunoelectron microscopic localization of the opioid growth factor receptor (OGFr) and OGF in the cornea. 2003 Mar 28. Brain Res. 967(1-2):37-47. National Eye Institute Reiter CE. Gardner TW. Functions of insulin and insulin receptor signaling in retina: possible implications for diabetic retinopathy. 2003 Jul. Prog Retin Eye Res. 22(4):545-62. National Eye Institute Barber AJ. Antonetti DA. Mapping the blood vessels with paracellular permeability in the retinas of diabetic rats. 2003 Dec. Invest Ophthalmol Vis Sci. 44(12):5410-6. National Eye Institute Antonetti DA. Wolpert EB. Isolation and characterization of retinal endothelial cells. 2003. Methods Mol Med. 89:365-74. National Eye Institute Zhang SS. Fu XY. Barnstable CJ. Molecular aspects of vertebrate retinal development. 2002 Oct-Dec. Mol Neurobiol. 26(2-3):137-52. National Eye Institute Public Health Service Zagon IS. Jenkins JB. Sassani JW. Wylie JD. Ruth TB. Fry JL. Lang CM. McLaughlin PJ. Naltrexone, an opioid antagonist, facilitates reepithelialization of the cornea in diabetic rat. 2002 Oct. Diabetes. 51(10):3055-62. National Eye Institute National Center for Research Resources Zagon IS. Verderame MF. McLaughlin PJ. The biology of the opioid growth factor receptor (OGFr). 2002 Feb. Brain Res Brain Res Rev. 38(3):351-76. National Cancer Institute National Eye Institute Antonetti DA. Wolpert EB. DeMaio L. Harhaj NS. Scaduto RC. Hydrocortisone decreases retinal endothelial cell water and solute flux coincident with increased content and decreased phosphorylation of occludin. 2002 Feb. J Neurochem. 80(4):667-77. National Eye Institute Gardner TW. Antonetti DA. Barber AJ. LaNoue KF. Levison SW. Diabetic retinopathy: more than meets the eye. 2002 Dec. Surv Ophthalmol. 47 Suppl 2:S253-62. National Eye Institute Harhaj NS. Barber AJ. Antonetti DA. Platelet-derived growth factor mediates tight junction redistribution and increases permeability in MDCK cells. 2002 Dec. J Cell Physiol. 193(3):349-64. National Eye Institute Zhang SS. Fu XY. Barnstable CJ. Tissue culture studies of retinal development. 2002 Dec. Methods. 28(4):439-47. National Eye Institute Public Health Service Nakamura M. Barber AJ. Antonetti DA. LaNoue KF. Robinson KA. Buse MG. Gardner TW. Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons. 2001 Nov 23. J Biol Chem. 276(47):43748-55. National Institute of Diabetes and Digestive and Kidney Diseases National Eye Institute Zagon IS. Sassani JW. Ruth TB. McLaughlin PJ. Epithelial adhesion complexes and organ culture of the human cornea. 2001 May 11. Brain Res. 900(2):205-13. National Eye Institute DeMaio L. Chang YS. Gardner TW. Tarbell JM. Antonetti DA. Shear stress regulates occludin content and phosphorylation. 2001 Jul. Am J Physiol Heart Circ Physiol. 281(1):H105-13. National Eye Institute National Heart, Lung, and Blood Institute Barber AJ. Nakamura M. Wolpert EB. Reiter CE. Seigel GM. Antonetti DA. Gardner TW. Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3. 2001 Aug 31. J Biol Chem. 276(35):32814-21. National Eye Institute Barber AJ. Antonetti DA. Gardner TW. Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. The Penn State Retina Research Group. 2000 Oct. Invest Ophthalmol Vis Sci. 41(11):3561-8. National Eye Institute Zagon IS. Sassani JW. Ruth TB. McLaughlin PJ. Cellular dynamics of corneal wound re-epithelialization in the rat. III. Mitotic activity. 2000 Nov 3. Brain Res. 882(1-2):169-79. National Eye Institute Chang YS. Munn LL. Hillsley MV. Dull RO. Yuan J. Lakshminarayanan S. Gardner TW. Jain RK. Tarbell JM. Effect of vascular endothelial growth factor on cultured endothelial cell monolayer transport properties. 2000 Mar. Microvasc Res. 59(2):265-77. National Eye Institute National Heart, Lung, and Blood Institute National Institute of General Medical Sciences Zagon IS. Sassani JW. McLaughlin PJ. Reepithelialization of the human cornea is regulated by endogenous opioids. 2000 Jan. Invest Ophthalmol Vis Sci. 41(1):73-81. National Eye Institute Zagon IS. Verderame MF. Zimmer WE. McLaughlin PJ. Molecular characterization and distribution of the opioid growth factor receptor (OGFr) in mouse. 2000 Dec 8. Brain Res Mol Brain Res. 84(1-2):106-14. National Cancer Institute National Eye Institute Lakshminarayanan S. Gardner TW. Tarbell JM. Effect of shear stress on the hydraulic conductivity of cultured bovine retinal microvascular endothelial cell monolayers. 2000 Dec. Curr Eye Res. 21(6):944-51. National Eye Institute National Heart, Lung, and Blood Institute Lakshminarayanan S. Antonetti DA. Gardner TW. Tarbell JM. Effect of VEGF on retinal microvascular endothelial hydraulic conductivity: the role of NO. 2000 Dec. Invest Ophthalmol Vis Sci. 41(13):4256-61. National Eye Institute National Heart, Lung, and Blood Institute Gardner TW. Antonetti DA. Barber AJ. LaNoue KF. Nakamura M. New insights into the pathophysiology of diabetic retinopathy: potential cell-specific therapeutic targets. 2000. Diabetes Technol Ther. 2(4):601-8. National Eye Institute Zagon IS. Sassani JW. McLaughlin PJ. Cellular dynamics of corneal wound re-epithelialization in the rat. I. Fate of ocular surface epithelial cells synthesizing DNA prior to wounding. 1999 Mar 20. Brain Res. 822(1-2):149-63. National Eye Institute Zagon IS. Wu Y. McLaughlin PJ. Opioid growth factor and organ development in rat and human embryos. 1999 Aug 28. Brain Res. 839(2):313-22. National Eye Institute National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke Zagon IS. Sassani JW. McLaughlin PJ. Cellular dynamics of corneal wound re-epithelialization in the rat. II. DNA synthesis of the ocular surface epithelium following wounding. 1999 Aug 28. Brain Res. 839(2):243-52. National Eye Institute Antonetti DA. Barber AJ. Hollinger LA. Wolpert EB. Gardner TW. Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors. 1999 Aug 13. J Biol Chem. 274(33):23463-7. National Eye Institute Hurst WJ. Zagon IS. Aboul-Enein HY. A rapid sample preparation method for the HPLC determination of the opioid antagonist naltrexone in serum. 1999 Aug. Pharmazie. 54(8):595-6. National Eye Institute Zagon IS. Sassani JW. Wu Y. McLaughlin PJ. The autocrine derivation of the opioid growth factor, [Met5]-enkephalin, in ocular surface epithelium. 1998 May 4. Brain Res. 792(1):72-8. National Eye Institute Zagon IS. Sassani JW. McLaughlin PJ. Re-epithelialization of the rat cornea is accelerated by blockade of opioid receptors. 1998 Jul 6. Brain Res. 798(1-2):254-60. National Eye Institute Antonetti DA. Barber AJ. Khin S. Lieth E. Tarbell JM. Gardner TW. Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group. 1998 Dec. Diabetes. 47(12):1953-9. National Eye Institute Zagon IS. Sassani JW. McLaughlin PJ. Re-epithelialization of the rabbit cornea is regulated by opioid growth factor. 1998 Aug 24. Brain Res. 803(1-2):61-8. National Eye Institute Barber AJ. Lieth E. Khin SA. Antonetti DA. Buchanan AG. Gardner TW. Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin. 1998 Aug 15. J Clin Invest. 102(4):783-91. National Eye Institute Gardner TW. Lieth E. Khin SA. Barber AJ. Bonsall DJ. Lesher T. Rice K. Brennan WA. Astrocytes increase barrier properties and ZO-1 expression in retinal vascular endothelial cells. 1997 Oct. Invest Ophthalmol Vis Sci. 38(11):2423-7. National Eye Institute Zagon IS. Sassani JW. Kane ER. McLaughlin PJ. Homeostasis of ocular surface epithelium in the rat is regulated by opioid growth factor. 1997 Jun 6. Brain Res. 759(1):92-102. National Eye Institute Yaccino JA. Chang YS. Hollis TM. Gardner TW. Tarbell JM. Physiological transport properties of cultured retinal microvascular endothelial cell monolayers. 1997 Aug. Curr Eye Res. 16(8):761-8. National Eye Institute National Institute of General Medical Sciences Zagon IS. Hurst WJ. McLaughlin PJ. Identification of [Met5]-enkephalin in developing, adult, and renewing tissues by reversed-phase high performance liquid chromatography and radioimmunoassay. 1997. Life Sci. 61(4):363-70. National Eye Institute National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke Gardner TW. Lesher T. Khin S. Vu C. Barber AJ. Brennan WA. Histamine reduces ZO-1 tight-junction protein expression in cultured retinal microvascular endothelial cells. 1996 Dec 15. Biochem J. 320 ( Pt 3):717-21. National Eye Institute Kimball SR. Chen SJ. Risica R. Jefferson LS. Leure-duPree AE. Effects of zinc deficiency on protein synthesis and expression of specific mRNAs in rat liver. 1995 Jan. Metabolism. 44(1):126-33. National Institute of Diabetes and Digestive and Kidney Diseases National Eye Institute Gardner TW. Klein R. Moss SE. Ferris FL. Remaley NA. Digoxin does not accelerate progression of diabetic retinopathy. 1995 Feb. Diabetes Care. 18(2):237-40. National Eye Institute Gardner TW. Eller AW. Friberg TR. D'Antonio JA. Hollis TM. Antihistamines reduce blood-retinal barrier permeability in type I (insulin-dependent) diabetic patients with nonproliferative retinopathy. A pilot study. 1995. Retina. 15(2):134-40. National Eye Institute Salloum RM. Stevens BR. Schultz GS. Souba WW. Regulation of small intestinal glutamine transport by epidermal growth factor. 1993 May. Surgery. 113(5):552-9. National Cancer Institute National Institute of Diabetes and Digestive and Kidney Diseases National Eye Institute Aiello PD. Trautmann JC. McPhee TJ. Kunselman AR. Hunder GG. Visual prognosis in giant cell arteritis. 1993 Apr. Ophthalmology. 100(4):550-5. National Eye Institute Kim U. Gregory E. Hall WC. Pathway from the zona incerta to the superior colliculus in the rat. 1992 Jul 22. J Comp Neurol. 321(4):555-75. National Eye Institute Cheng HM. Aguayo JB. Moore GJ. Mattingly M. Analysis of diabetic cataractogenesis using chemical-shift nuclear magnetic resonance microscopy. 1991 Jan. Magn Reson Med. 17(1):62-8. National Eye Institute Schneider BG. Shyjan AW. Levenson R. Co-localization and polarized distribution of Na,K-ATPase alpha 3 and beta 2 subunits in photoreceptor cells. 1991 Apr. J Histochem Cytochem. 39(4):507-17. National Eye Institute Scialfa CT. Leibowitz HW. Gish KW. Age differences in peripheral refractive error. 1989 Sep. Psychol Aging. 4(3):372-5. National Institute on Aging National Eye Institute Liao CC. Lin HS. Liu JY. Hibbard LS. Wu JY. Purification and characterization of a benzodiazepine-like substance from mammalian brain. 1989 Apr. Neurochem Res. 14(4):345-52. National Eye Institute National Institute of Neurological Disorders and Stroke Leibowitz HW. Gish KW. Sheehy JB. Role of vergence accommodation in correcting for night myopia. 1988 May. Am J Optom Physiol Opt. 65(5):383-6. National Eye Institute Rose RC. Transport of ascorbic acid and other water-soluble vitamins. 1988 Jun 9. Biochim Biophys Acta. 947(2):335-66. National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases National Eye Institute National Institute of Child Health and Human Development Scialfa CT. Tyrrell RA. Garvey PM. Deering LM. Leibowitz HW. Goebel CC. Age differences in Vistech near contrast sensitivity. 1988 Dec. Am J Optom Physiol Opt. 65(12):951-6. National Institute on Aging National Eye Institute Leure-duPree AE. Connor MJ. The effect of deferoxamine, an iron chelator, on the morphology of the retina. 1987. Prog Clin Biol Res. 247:517-29. National Eye Institute Wu JY. Johansen FF. Lin CT. Liu JW. Taurine system in the normal and ischemic rat hippocampus. 1987. Adv Exp Med Biol. 217:265-74. National Eye Institute National Institute of Neurological Disorders and Stroke Leure-Dupree AE. Bridges CD. Changes in retinal morphology and vitamin A metabolism as a consequence of decreased zinc availability. 1982. Retina. 2(4):294-302. National Eye Institute