Craig Cameron All publications ( 47 ) Te Velthuis AJ. Arnold JJ. Cameron CE. van den Worm SH. Snijder EJ. The RNA polymerase activity of SARS-coronavirus nsp12 is primer dependent. 2010 Jan 1. Nucleic Acids Res. 38(1):203-214. Castro C. Smidansky ED. Arnold JJ. Maksimchuk KR. Moustafa I. Uchida A. Götte M. Konigsberg W. Cameron CE. Nucleic acid polymerases use a general acid for nucleotidyl transfer. 2009 Feb. Nat Struct Mol Biol. 16(2):212-8. Wang Q. Arnold JJ. Uchida A. Raney KD. Cameron CE. Phosphate release contributes to the rate-limiting step for unwinding by an RNA helicase. 2009 Dec 6. Nucleic Acids Res. . Cameron CE. Moustafa IM. Arnold JJ. Dynamics: the missing link between structure and function of the viral RNA-dependent RNA polymerase? 2009 Dec. Curr Opin Struct Biol. 19(6):768-74. Pathak HB. Oh HS. Goodfellow IG. Arnold JJ. Cameron CE. Picornavirus Genome Replication: ROLES OF PRECURSOR PROTEINS AND RATE-LIMITING STEPS IN oriI-DEPENDENT VPg URIDYLYLATION. 2008 Nov 7. J Biol Chem. 283(45):30677-88. Amero CD. Arnold JJ. Moustafa IM. Cameron CE. Foster MP. Identification of the oriI-binding site of poliovirus 3C protein by nuclear magnetic resonance spectroscopy. 2008 May. J Virol. 82(9):4363-70. Graci JD. Too K. Smidansky ED. Edathil JP. Barr EW. Harki DA. Galarraga JE. Bollinger JM. Peterson BR. Loakes D. Brown DM. Cameron CE. Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues. 2008 Mar. Antimicrob Agents Chemother. 52(3):971-9. Jennings TA. Chen Y. Sikora D. Harrison MK. Sikora B. Huang L. Jankowsky E. Fairman ME. Cameron CE. Raney KD. RNA unwinding activity of the hepatitis C virus NS3 helicase is modulated by the NS5B polymerase. 2008 Jan 29. Biochemistry. 47(4):1126-35. Shen M. Reitman ZJ. Zhao Y. Moustafa I. Wang Q. Arnold JJ. Pathak HB. Cameron CE. Picornavirus genome replication. Identification of the surface of the poliovirus (PV) 3C dimer that interacts with PV 3Dpol during VPg uridylylation and construction of a structural model for the PV 3C2-3Dpol complex. 2008 Jan 11. J Biol Chem. 283(2):875-88. Arias A. Arnold JJ. Sierra M. Smidansky ED. Domingo E. Cameron CE. Determinants of RNA-dependent RNA polymerase (in)fidelity revealed by kinetic analysis of the polymerase encoded by a foot-and-mouth disease virus mutant with reduced sensitivity to ribavirin. 2008 Dec. J Virol. 82(24):12346-55. Nallagatla SR. Hwang J. Toroney R. Zheng X. Cameron CE. Bevilacqua PC. 5'-triphosphate-dependent activation of PKR by RNAs with short stem-loops. 2007 Nov 30. Science. 318(5855):1455-8. Shen M. Wang Q. Yang Y. Pathak HB. Arnold JJ. Castro C. Lemon SM. Cameron CE. Human rhinovirus type 14 gain-of-function mutants for oriI utilization define residues of 3C(D) and 3Dpol that contribute to assembly and stability of the picornavirus VPg uridylylation complex. 2007 Nov. J Virol. 81(22):12485-95. Castro C. Smidansky E. Maksimchuk KR. Arnold JJ. Korneeva VS. Götte M. Konigsberg W. Cameron CE. Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases. 2007 Mar 13. Proc Natl Acad Sci U S A. 104(11):4267-72. National Institute of Allergy and Infectious Diseases Korneeva VS. Cameron CE. Structure-function relationships of the viral RNA-dependent RNA polymerase: fidelity, replication speed, and initiation mechanism determined by a residue in the ribose-binding pocket. 2007 Jun 1. J Biol Chem. 282(22):16135-45. National Institute of Allergy and Infectious Diseases Pathak HB. Arnold JJ. Wiegand PN. Hargittai MR. Cameron CE. Picornavirus genome replication: assembly and organization of the VPg uridylylation ribonucleoprotein (initiation) complex. 2007 Jun 1. J Biol Chem. 282(22):16202-13. National Institute of Allergy and Infectious Diseases Graci JD. Harki DA. Korneeva VS. Edathil JP. Too K. Franco D. Smidansky ED. Paul AV. Peterson BR. Brown DM. Loakes D. Cameron CE. Lethal Mutagenesis of Poliovirus Mediated by a Mutagenic Pyrimidine Analogue. 2007 Aug 8. J Virol. . Harki DA. Graci JD. Edathil JP. Castro C. Cameron CE. Peterson BR. Synthesis of a Universal 5-Nitroindole Ribonucleotide and Incorporation into RNA by a Viral RNA-Dependent RNA Polymerase. 2007 Aug 13. Chembiochem. 8(12):1359-1362. Marcotte LL. Wass AB. Gohara DW. Pathak HB. Arnold JJ. Filman DJ. Cameron CE. Hogle JM. Crystal structure of poliovirus 3CD protein: virally encoded protease and precursor to the RNA-dependent RNA polymerase. 2007 Apr. J Virol. 81(7):3583-96. National Institute of Allergy and Infectious Diseases Harki DA. Graci JD. Galarraga JE. Chain WJ. Cameron CE. Peterson BR. Synthesis and antiviral activity of 5-substituted cytidine analogues: identification of a potent inhibitor of viral RNA-dependent RNA polymerases. 2006 Oct 19. J Med Chem. 49(21):6166-9. National Institute of Allergy and Infectious Diseases Arnold JJ. Bernal A. Uche U. Sterner DE. Butt TR. Cameron CE. Mattern MR. Small ubiquitin-like modifying protein isopeptidase assay based on poliovirus RNA polymerase activity. 2006 Mar 15. Anal Biochem. 350(2):214-21. National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Neurological Disorders and Stroke Graci JD. Cameron CE. Mechanisms of action of ribavirin against distinct viruses. 2006 Jan-Feb. Rev Med Virol. 16(1):37-48. National Institute of Allergy and Infectious Diseases Huang L. Hwang J. Sharma SD. Hargittai MR. Chen Y. Arnold JJ. Raney KD. Cameron CE. Hepatitis C virus nonstructural protein 5A (NS5A) is an RNA-binding protein. 2005 Oct 28. J Biol Chem. 280(43):36417-28. National Institute of Allergy and Infectious Diseases Arnold JJ. Vignuzzi M. Stone JK. Andino R. Cameron CE. Remote site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymerase. 2005 Jul 8. J Biol Chem. 280(27):25706-16. National Institute of Allergy and Infectious Diseases Castro C. Arnold JJ. Cameron CE. Incorporation fidelity of the viral RNA-dependent RNA polymerase: a kinetic, thermodynamic and structural perspective. 2005 Feb. Virus Res. 107(2):141-9. National Institute of Allergy and Infectious Diseases Huang L. Sineva EV. Hargittai MR. Sharma SD. Suthar M. Raney KD. Cameron CE. Purification and characterization of hepatitis C virus non-structural protein 5A expressed in Escherichia coli. 2004 Sep. Protein Expr Purif. 37(1):144-53. National Institute of Allergy and Infectious Diseases Gohara DW. Arnold JJ. Cameron CE. Poliovirus RNA-dependent RNA polymerase (3Dpol): kinetic, thermodynamic, and structural analysis of ribonucleotide selection. 2004 May 11. Biochemistry. 43(18):5149-58. National Institute of Allergy and Infectious Diseases National Cancer Institute Arnold JJ. Gohara DW. Cameron CE. Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mn2+. 2004 May 11. Biochemistry. 43(18):5138-48. National Institute of Allergy and Infectious Diseases National Cancer Institute Arnold JJ. Cameron CE. Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mg2+. 2004 May 11. Biochemistry. 43(18):5126-37. National Institute of Allergy and Infectious Diseases National Cancer Institute Graci JD. Cameron CE. Challenges for the development of ribonucleoside analogues as inducers of error catastrophe. 2004 Jan. Antivir Chem Chemother. 15(1):1-13. National Institute of Allergy and Infectious Diseases de Miranda JR. Drebot M. Tyler S. Shen M. Cameron CE. Stoltz DB. Camazine SM. Complete nucleotide sequence of Kashmir bee virus and comparison with acute bee paralysis virus. 2004 Aug. J Gen Virol. 85(Pt 8):2263-70. Graci JD. Cameron CE. Quasispecies, error catastrophe, and the antiviral activity of ribavirin. 2002 Jul 5. Virology. 298(2):175-80. Harki DA. Graci JD. Korneeva VS. Ghosh SK. Hong Z. Cameron CE. Peterson BR. Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-beta-D-Ribofuranosyl-3-nitropyrrole. 2002 Jul 23. Biochemistry. 41(29):9026-33. National Cancer Institute Pathak HB. Ghosh SK. Roberts AW. Sharma SD. Yoder JD. Arnold JJ. Gohara DW. Barton DJ. Paul AV. Cameron CE. Structure-function relationships of the RNA-dependent RNA polymerase from poliovirus (3Dpol). A surface of the primary oligomerization domain functions in capsid precursor processing and VPg uridylylation. 2002 Aug 30. J Biol Chem. 277(35):31551-62. National Institute of Allergy and Infectious Diseases National Cancer Institute Wei L. Huhn JS. Mory A. Pathak HB. Sosnovtsev SV. Green KY. Cameron CE. Proteinase-polymerase precursor as the active form of feline calicivirus RNA-dependent RNA polymerase. 2001 Feb. J Virol. 75(3):1211-9. National Cancer Institute Maag D. Castro C. Hong Z. Cameron CE. Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin. 2001 Dec 7. J Biol Chem. 276(49):46094-8. National Cancer Institute Cameron CE. Castro C. The mechanism of action of ribavirin: lethal mutagenesis of RNA virus genomes mediated by the viral RNA-dependent RNA polymerase. 2001 Dec. Curr Opin Infect Dis. 14(6):757-64. Arnold JJ. Cameron CE. Poliovirus RNA-dependent RNA polymerase (3D(pol)). Assembly of stable, elongation-competent complexes by using a symmetrical primer-template substrate (sym/sub). 2000 Feb 25. J Biol Chem. 275(8):5329-36. National Institute of Allergy and Infectious Diseases National Cancer Institute Gohara DW. Crotty S. Arnold JJ. Yoder JD. Andino R. Cameron CE. Poliovirus RNA-dependent RNA polymerase (3Dpol): structural, biochemical, and biological analysis of conserved structural motifs A and B. 2000 Aug 18. J Biol Chem. 275(33):25523-32. National Institute of Allergy and Infectious Diseases National Cancer Institute Arnold JJ. Ghosh SK. Bevilacqua PC. Cameron CE. Single-nucleotide resolution of RNA strands in the presence of their RNA complements. 1999 Sep. Biotechniques. 27(3):450-2, 454, 456. National Cancer Institute National Institute of General Medical Sciences Gohara DW. Ha CS. Kumar S. Ghosh B. Arnold JJ. Wisniewski TJ. Cameron CE. Production of "authentic" poliovirus RNA-dependent RNA polymerase (3D(pol)) by ubiquitin-protease-mediated cleavage in Escherichia coli. 1999 Oct. Protein Expr Purif. 17(1):128-38. National Cancer Institute Arnold JJ. Cameron CE. Poliovirus RNA-dependent RNA polymerase (3Dpol) is sufficient for template switching in vitro. 1999 Jan 29. J Biol Chem. 274(5):2706-16. National Cancer Institute Arnold JJ. Ghosh SK. Cameron CE. Poliovirus RNA-dependent RNA polymerase (3D(pol)). Divalent cation modulation of primer, template, and nucleotide selection. 1999 Dec 24. J Biol Chem. 274(52):37060-9. National Cancer Institute Cameron CE. Ghosh M. Le Grice SF. Benkovic SJ. Mutations in HIV reverse transcriptase which alter RNase H activity and decrease strand transfer efficiency are suppressed by HIV nucleocapsid protein. 1997 Jun 24. Proc Natl Acad Sci U S A. 94(13):6700-5. National Institute of Allergy and Infectious Diseases National Institute of General Medical Sciences Cameron CE. Benkovic SJ. Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant. 1997 Dec 16. Biochemistry. 36(50):15792-800. National Institute of Allergy and Infectious Diseases National Institute of General Medical Sciences Xiang Y. Cameron CE. Wills JW. Leis J. Fine mapping and characterization of the Rous sarcoma virus Pr76gag late assembly domain. 1996 Aug. J Virol. 70(8):5695-700. National Cancer Institute Benkovic SJ. Cameron CE. Kinetic analysis of nucleotide incorporation and misincorporation by Klenow fragment of Escherichia coli DNA polymerase I. 1995. Methods Enzymol. 262:257-69. National Institute of Allergy and Infectious Diseases National Institute of General Medical Sciences Wills JW. Cameron CE. Wilson CB. Xiang Y. Bennett RP. Leis J. An assembly domain of the Rous sarcoma virus Gag protein required late in budding. 1994 Oct. J Virol. 68(10):6605-18. National Cancer Institute