Charles D. Smith
Photo
Academic title Professor of Pharmacology
College College of Medicine
Campuses Penn State Milton S. Hershey Medical Center
Department Pharmacology
Graduate programs Integrative Biosciences
Pharmacology
MD/PhD Degree Program
Email Phone
  cds9@psu.edu
  717 531 1672
 
Educational background
  Ph.D., Michigan State University, 1984
Postdoctoral Training, Duke University, 1984-1986
Research interests
 

Development of Novel Anticancer Agents

The main interests of this laboratory relate to cancer pharmacology, with focus on studying the molecular mechanisms of action of established and experimental anticancer drugs, and cellular mechanisms for the development of resistance to anticancer agents. Our overall goal is to improve cancer chemotherapy by developing new drugs which are effective against tumors which have developed resistance to currently available drugs. Three projects are currently in progress:

  • Design of Drug Transporters Antagonists

  • Biochemistry And Pharmacology Of ras Oncoproteins

  • Mechanisms of Action of Novel Cytoskeletal Poisons

These efforts all utilize a multidisciplinary approach which includes: biochemical characterization of selected targets for anticancer drugs, synthesis of novel inhibitors of these targets, and pharmacological evaluation of the activities of these compounds in both in vitro and in vivo model systems.

Areas of expertise
 
Drug Resistance, MultipleAntineoplastic Agents
Palmitic AcidCerulenin
ras ProteinsFluorescent Dyes
Protein Processing, Post-TranslationalPeptides, Cyclic
P-GlycoproteinQuinoxalines
AmidesEpoxy Compounds
Alkyl and Aryl TransferasesEnzyme Inhibitors
AcyltransferasesChromatography, High Pressure Liquid
Palmitoyl Coenzyme APeptide Fragments
Phosphotransferases (Alcohol Group Acceptor)Pyrroles
QuinolinesDisease Models, Animal
PyrazinesCyclic AMP
CarbamazepineCyclic GMP
Affective Disorders, PsychoticMelanoma
MutationProto-Oncogene Proteins B-raf
AnticonvulsantsAntipsychotic Agents
ClozapineEndothelial Cells
ParoxetinePhenytoin
RetinaSerotonin Uptake Inhibitors
ApoptosisBenzenesulfonates
Colorectal NeoplasmsPyridines
LipoproteinsPeptides
Publication author name
  Smith C
Smith CD
Select publications
  Xia Z. Smith CD. Efficient synthesis of a fluorescent farnesylated Ras peptide. 2001 Jul 27. J Org Chem. 66(15):5241-4.
National Cancer Institute
Smith CD. Myers CB. Zilfou JT. Smith SN. Lawrence DS. Indoloquinoxaline compounds that selectively antagonize P-glycoprotein. 2000. Oncol Res. 12(5):219-29.
National Cancer Institute
Lawrence DS. Copper JE. Smith CD. Structure-activity studies of substituted quinoxalinones as multiple-drug-resistance antagonists. 2001 Feb 15. J Med Chem. 44(4):594-601.
National Cancer Institute
Xia Z. Smith CD. Total synthesis of dendroamide A, a novel cyclic peptide that reverses multiple drug resistance. 2001 May 18. J Org Chem. 66(10):3459-66.
National Cancer Institute
Varner AS. De Vos ML. Creaser SP. Peterson BR. Smith CD. A fluorescence-based high performance liquid chromatographic method for the characterization of palmitoyl acyl transferase activity. 2002 Sep 1. Anal Biochem. 308(1):160-7.
National Cancer Institute
Technician Employment Opportunities
 
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