David A. Antonetti All publications ( 39 ) Gardner TW. Antonetti DA. A prize catch for diabetic retinopathy. 2007 Feb. Nat Med. 13(2):131-2. Erickson KK. Sundstrom JM. Antonetti DA. Vascular permeability in ocular disease and the role of tight junctions. 2007. Angiogenesis. 10(2):103-17. National Eye Institute Antonetti DA. Barber AJ. Bronson SK. Freeman WM. Gardner TW. Jefferson LS. Kester M. Kimball SR. Krady JK. LaNoue KF. Norbury CC. Quinn PG. Sandirasegarane L. Simpson IA. JDRF Diabetic Retinopathy Center Group. Diabetic retinopathy: seeing beyond glucose-induced microvascular disease. 2006 Sep. Diabetes. 55(9):2401-11. National Eye Institute Harhaj NS. Felinski EA. Wolpert EB. Sundstrom JM. Gardner TW. Antonetti DA. VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability. 2006 Nov. Invest Ophthalmol Vis Sci. 47(11):5106-15. National Eye Institute Maines LW. French KJ. Wolpert EB. Antonetti DA. Smith CD. Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases. 2006 Nov. Invest Ophthalmol Vis Sci. 47(11):5022-31. National Eye Institute Gardner TW. Antonetti DA. Ruboxistaurin for diabetic retinopathy. 2006 Dec. Ophthalmology. 113(12):2135-6. Reiter CE. Wu X. Sandirasegarane L. Nakamura M. Gilbert KA. Singh RS. Fort PE. Antonetti DA. Gardner TW. Diabetes reduces basal retinal insulin receptor signaling: reversal with systemic and local insulin. 2006 Apr. Diabetes. 55(4):1148-56. National Eye Institute National Institute of General Medical Sciences Zinnanti WJ. Lazovic J. Wolpert EB. Antonetti DA. Smith MB. Connor JR. Woontner M. Goodman SI. Cheng KC. A diet-induced mouse model for glutaric aciduria type I. 2006 Apr. Brain. 129(Pt 4):899-910. National Institute for Biomedical Imaging and Bioengineering Maines LW. Antonetti DA. Wolpert EB. Smith CD. Evaluation of the role of P-glycoprotein in the uptake of paroxetine, clozapine, phenytoin and carbamazapine by bovine retinal endothelial cells. 2005 Oct. Neuropharmacology. 49(5):610-7. National Eye Institute Pang Z. Antonetti DA. Tarbell JM. Shear stress regulates HUVEC hydraulic conductivity by occludin phosphorylation. 2005 Nov. Ann Biomed Eng. 33(11):1536-45. National Heart, Lung, and Blood Institute Felinski EA. Antonetti DA. Glucocorticoid regulation of endothelial cell tight junction gene expression: novel treatments for diabetic retinopathy. 2005 Nov. Curr Eye Res. 30(11):949-57. Barber AJ. Antonetti DA. Kern TS. Reiter CE. Soans RS. Krady JK. Levison SW. Gardner TW. Bronson SK. The Ins2Akita mouse as a model of early retinal complications in diabetes. 2005 Jun. Invest Ophthalmol Vis Sci. 46(6):2210-8. National Eye Institute Wu X. Reiter CE. Antonetti DA. Kimball SR. Jefferson LS. Gardner TW. Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner. 2004 Mar 5. J Biol Chem. 279(10):9167-75. National Institute of Diabetes and Digestive and Kidney Diseases National Eye Institute Harhaj NS. Antonetti DA. Regulation of tight junctions and loss of barrier function in pathophysiology. 2004 Jul. Int J Biochem Cell Biol. 36(7):1206-37. DeMaio L. Tarbell JM. Scaduto RC. Gardner TW. Antonetti DA. A transmural pressure gradient induces mechanical and biological adaptive responses in endothelial cells. 2004 Feb. Am J Physiol Heart Circ Physiol. 286(2):H731-41. National Eye Institute National Heart, Lung, and Blood Institute Reiter CE. Sandirasegarane L. Wolpert EB. Klinger M. Simpson IA. Barber AJ. Antonetti DA. Kester M. Gardner TW. Characterization of insulin signaling in rat retina in vivo and ex vivo. 2003 Oct. Am J Physiol Endocrinol Metab. 285(4):E763-74. National Institute of General Medical Sciences Barber AJ. Antonetti DA. Mapping the blood vessels with paracellular permeability in the retinas of diabetic rats. 2003 Dec. Invest Ophthalmol Vis Sci. 44(12):5410-6. National Eye Institute Burdo JR. Antonetti DA. Wolpert EB. Connor JR. Mechanisms and regulation of transferrin and iron transport in a model blood-brain barrier system. 2003. Neuroscience. 121(4):883-90. Antonetti DA. Wolpert EB. Isolation and characterization of retinal endothelial cells. 2003. Methods Mol Med. 89:365-74. National Eye Institute Antonetti DA. Wolpert EB. DeMaio L. Harhaj NS. Scaduto RC. Hydrocortisone decreases retinal endothelial cell water and solute flux coincident with increased content and decreased phosphorylation of occludin. 2002 Feb. J Neurochem. 80(4):667-77. National Eye Institute Gardner TW. Antonetti DA. Barber AJ. LaNoue KF. Levison SW. Diabetic retinopathy: more than meets the eye. 2002 Dec. Surv Ophthalmol. 47 Suppl 2:S253-62. National Eye Institute Harhaj NS. Barber AJ. Antonetti DA. Platelet-derived growth factor mediates tight junction redistribution and increases permeability in MDCK cells. 2002 Dec. J Cell Physiol. 193(3):349-64. National Eye Institute Nakamura M. Barber AJ. Antonetti DA. LaNoue KF. Robinson KA. Buse MG. Gardner TW. Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons. 2001 Nov 23. J Biol Chem. 276(47):43748-55. National Institute of Diabetes and Digestive and Kidney Diseases National Eye Institute DeMaio L. Chang YS. Gardner TW. Tarbell JM. Antonetti DA. Shear stress regulates occludin content and phosphorylation. 2001 Jul. Am J Physiol Heart Circ Physiol. 281(1):H105-13. National Eye Institute National Heart, Lung, and Blood Institute Barber AJ. Nakamura M. Wolpert EB. Reiter CE. Seigel GM. Antonetti DA. Gardner TW. Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3. 2001 Aug 31. J Biol Chem. 276(35):32814-21. National Eye Institute Barber AJ. Antonetti DA. Gardner TW. Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. The Penn State Retina Research Group. 2000 Oct. Invest Ophthalmol Vis Sci. 41(11):3561-8. National Eye Institute Lieth E. LaNoue KF. Antonetti DA. Ratz M. Diabetes reduces glutamate oxidation and glutamine synthesis in the retina. The Penn State Retina Research Group. 2000 Jun. Exp Eye Res. 70(6):723-30. Lieth E. Gardner TW. Barber AJ. Antonetti DA. Penn State Retina Research Group. Retinal neurodegeneration: early pathology in diabetes. 2000 Feb. Clin Experiment Ophthalmol. 28(1):3-8. Lakshminarayanan S. Antonetti DA. Gardner TW. Tarbell JM. Effect of VEGF on retinal microvascular endothelial hydraulic conductivity: the role of NO. 2000 Dec. Invest Ophthalmol Vis Sci. 41(13):4256-61. National Eye Institute National Heart, Lung, and Blood Institute Gardner TW. Antonetti DA. Barber AJ. LaNoue KF. Nakamura M. New insights into the pathophysiology of diabetic retinopathy: potential cell-specific therapeutic targets. 2000. Diabetes Technol Ther. 2(4):601-8. National Eye Institute Shah OJ. Antonetti DA. Kimball SR. Jefferson LS. Leucine, glutamine, and tyrosine reciprocally modulate the translation initiation factors eIF4F and eIF2B in perfused rat liver. 1999 Dec 17. J Biol Chem. 274(51):36168-75. National Institute of Diabetes and Digestive and Kidney Diseases Antonetti DA. Lieth E. Barber AJ. Gardner TW. Molecular mechanisms of vascular permeability in diabetic retinopathy. 1999 Dec. Semin Ophthalmol. 14(4):240-8. Antonetti DA. Barber AJ. Hollinger LA. Wolpert EB. Gardner TW. Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors. 1999 Aug 13. J Biol Chem. 274(33):23463-7. National Eye Institute Gardner TW. Antonetti DA. Barber AJ. Lieth E. Tarbell JA. The molecular structure and function of the inner blood-retinal barrier. Penn State Retina Research Group. 1999. Doc Ophthalmol. 97(3-4):229-37. Antonetti DA. Barber AJ. Khin S. Lieth E. Tarbell JM. Gardner TW. Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group. 1998 Dec. Diabetes. 47(12):1953-9. National Eye Institute Barber AJ. Lieth E. Khin SA. Antonetti DA. Buchanan AG. Gardner TW. Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin. 1998 Aug 15. J Clin Invest. 102(4):783-91. National Eye Institute Antonetti DA. Kimball SR. Horetsky RL. Jefferson LS. Regulation of rDNA transcription by insulin in primary cultures of rat hepatocytes. 1993 Dec 5. J Biol Chem. 268(34):25277-84. National Institute of Diabetes and Digestive and Kidney Diseases Hsu CJ. Kimball SR. Antonetti DA. Jefferson LS. Effects of insulin on total RNA, poly(A)+ RNA, and mRNA in primary cultures of rat hepatocytes. 1992 Dec. Am J Physiol. 263(6 Pt 1):E1106-12. National Institute of Diabetes and Digestive and Kidney Diseases Kimball SR. Antonetti DA. Brawley RM. Jefferson LS. Mechanism of inhibition of peptide chain initiation by amino acid deprivation in perfused rat liver. Regulation involving inhibition of eukaryotic initiation factor 2 alpha phosphatase activity. 1991 Jan 25. J Biol Chem. 266(3):1969-76. National Institute of Diabetes and Digestive and Kidney Diseases