Douglas Cavener All publications ( 10 ) Kimball SR. Do AN. Kutzler L. Cavener DR. Jefferson LS. Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis. 2008 Feb 8. J Biol Chem. 283(6):3465-75. Wei J. Sheng X. Feng D. McGrath B. Cavener DR. PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation. 2008 Aug 6. J Cell Physiol. . Guo F. Cavener DR. The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. 2007 Feb. Cell Metab. 5(2):103-14. National Institute of Diabetes and Digestive and Kidney Diseases National Institute of General Medical Sciences Iida K. Cox-Foster DL. Yang X. Ko WY. Cavener DR. Expansion and evolution of insect GMC oxidoreductases. 2007. BMC Evol Biol. 7:75. National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institute of Diabetes and Digestive and Kidney Diseases Liang SH. Zhang W. McGrath BC. Zhang P. Cavener DR. PERK (eIF2alpha kinase) is required to activate the stress-activated MAPKs and induce the expression of immediate-early genes upon disruption of ER calcium homoeostasis. 2006 Jan 1. Biochem J. 393(Pt 1):201-9. National Institute of Diabetes and Digestive and Kidney Diseases Zhang W. Feng D. Li Y. Iida K. McGrath B. Cavener DR. PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis. 2006 Dec. Cell Metab. 4(6):491-7. National Institute of Diabetes and Digestive and Kidney Diseases National Institute of General Medical Sciences Iida K. Cavener DR. Glucose dehydrogenase is required for normal sperm storage and utilization in female Drosophila melanogaster. 2004 Feb. J Exp Biol. 207(Pt 4):675-81. Li Y. Iida K. O'Neil J. Zhang P. Li S. Frank A. Gabai A. Zambito F. Liang SH. Rosen CJ. Cavener DR. PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver. 2003 Aug. Endocrinology. 144(8):3505-13. National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institute of General Medical Sciences Zhang P. McGrath BC. Reinert J. Olsen DS. Lei L. Gill S. Wek SA. Vattem KM. Wek RC. Kimball SR. Jefferson LS. Cavener DR. The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. 2002 Oct. Mol Cell Biol. 22(19):6681-8. National Institute of Diabetes and Digestive and Kidney Diseases National Institute of General Medical Sciences Zhang P. McGrath B. Li S. Frank A. Zambito F. Reinert J. Gannon M. Ma K. McNaughton K. Cavener DR. The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. 2002 Jun. Mol Cell Biol. 22(11):3864-74. National Institute of General Medical Sciences