Gary Perdew All publications ( 40 ) Murray IA. Perdew GH. Omeprazole stimulates the induction of human insulin-like growth factor binding protein-1 through Ah receptor activation. 2007 Nov 30. J Pharmacol Exp Ther. . Chiaro CR. Patel RD. Marcus CB. Perdew GH. Evidence for an aryl hydrocarbon receptor-mediated cytochrome p450 autoregulatory pathway. 2007 Nov. Mol Pharmacol. 72(5):1369-79. Patel RD. Hollingshead BD. Omiecinski CJ. Perdew GH. Aryl-hydrocarbon receptor activation regulates constitutive androstane receptor levels in murine and human liver. 2007 Jul. Hepatology. 46(1):209-18. National Institute of Environmental Health Sciences National Institute of General Medical Sciences Morales JL. Perdew GH. Carboxyl terminus of hsc70-interacting protein (CHIP) can remodel mature aryl hydrocarbon receptor (AhR) complexes and mediate ubiquitination of both the AhR and the 90 kDa heat-shock protein (hsp90) in vitro. 2007 Jan 16. Biochemistry. 46(2):610-21. National Institute of Environmental Health Sciences Patel RD. Kim DJ. Peters JM. Perdew GH. The aryl hydrocarbon receptor directly regulates expression of the potent mitogen epiregulin. 2006 Jan. Toxicol Sci. 89(1):75-82. National Institute of Environmental Health Sciences Hollingshead BD. Patel RD. Perdew GH. Endogenous hepatic expression of the hepatitis B virus X-associated protein 2 is adequate for maximal association with aryl hydrocarbon receptor-90-kDa heat shock protein complexes. 2006 Dec. Mol Pharmacol. 70(6):2096-107. National Cancer Institute National Institute of Environmental Health Sciences Murray IA. Reen RK. Leathery N. Ramadoss P. Bonati L. Gonzalez FJ. Peters JM. Perdew GH. Evidence that ligand binding is a key determinant of Ah receptor-mediated transcriptional activity. 2005 Oct 1. Arch Biochem Biophys. 442(1):59-71. National Institute of Environmental Health Sciences Kim DJ. Murray IA. Burns AM. Gonzalez FJ. Perdew GH. Peters JM. Peroxisome proliferator-activated receptor-beta/delta inhibits epidermal cell proliferation by down-regulation of kinase activity. 2005 Mar 11. J Biol Chem. 280(10):9519-27. National Cancer Institute National Institute of Environmental Health Sciences Beischlag TV. Perdew GH. ER alpha-AHR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin-inducible gene transcription. 2005 Jun 3. J Biol Chem. 280(22):21607-11. National Institute of Environmental Health Sciences Ramadoss P. Perdew GH. The transactivation domain of the Ah receptor is a key determinant of cellular localization and ligand-independent nucleocytoplasmic shuttling properties. 2005 Aug 23. Biochemistry. 44(33):11148-59. National Institute of Environmental Health Sciences Hollingshead BD. Petrulis JR. Perdew GH. The aryl hydrocarbon (Ah) receptor transcriptional regulator hepatitis B virus X-associated protein 2 antagonizes p23 binding to Ah receptor-Hsp90 complexes and is dispensable for receptor function. 2004 Oct 29. J Biol Chem. 279(44):45652-61. National Institute of Environmental Health Sciences Ramadoss P. Perdew GH. Use of 2-azido-3-[125I]iodo-7,8-dibromodibenzo-p-dioxin as a probe to determine the relative ligand affinity of human versus mouse aryl hydrocarbon receptor in cultured cells. 2004 Jul. Mol Pharmacol. 66(1):129-36. National Institute of Environmental Health Sciences Ramadoss P. Petrulis JR. Hollingshead BD. Kusnadi A. Perdew GH. Divergent roles of hepatitis B virus X-associated protein 2 (XAP2) in human versus mouse Ah receptor complexes. 2004 Jan 27. Biochemistry. 43(3):700-9. National Institute of Environmental Health Sciences Sumanasekera WK. Tien ES. Davis JW. Turpey R. Perdew GH. Vanden Heuvel JP. Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activity. 2003 Sep 16. Biochemistry. 42(36):10726-35. National Institute of Environmental Health Sciences Petrulis JR. Kusnadi A. Ramadoss P. Hollingshead B. Perdew GH. The hsp90 Co-chaperone XAP2 alters importin beta recognition of the bipartite nuclear localization signal of the Ah receptor and represses transcriptional activity. 2003 Jan 24. J Biol Chem. 278(4):2677-85. National Institute of Environmental Health Sciences Sumanasekera WK. Tien ES. Turpey R. Vanden Heuvel JP. Perdew GH. Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2. 2003 Feb 14. J Biol Chem. 278(7):4467-73. National Institute of Environmental Health Sciences Petrulis JR. Perdew GH. The role of chaperone proteins in the aryl hydrocarbon receptor core complex. 2002 Sep 20. Chem Biol Interact. 141(1-2):25-40. National Institute of Environmental Health Sciences Dull AB. Carlson DB. Petrulis JR. Perdew GH. Characterization of the phosphorylation status of the hepatitis B virus X-associated protein 2. 2002 Oct 15. Arch Biochem Biophys. 406(2):209-21. National Institute of Environmental Health Sciences Reen RK. Cadwallader A. Perdew GH. The subdomains of the transactivation domain of the aryl hydrocarbon receptor (AhR) inhibit AhR and estrogen receptor transcriptional activity. 2002 Dec 1. Arch Biochem Biophys. 408(1):93-102. National Institute of Environmental Health Sciences Carlson DB. Perdew GH. A dynamic role for the Ah receptor in cell signaling? Insights from a diverse group of Ah receptor interacting proteins. 2002. J Biochem Mol Toxicol. 16(6):317-25. National Institute of Environmental Health Sciences Swanson HI. Whitelaw ML. Petrulis JR. Perdew GH. Use of [125I]4'-iodoflavone as a tool to characterize ligand-dependent differences in Ah receptor behavior. 2002. J Biochem Mol Toxicol. 16(6):298-310. National Institute of Environmental Health Sciences Levine SL. Perdew GH. Okadaic acid increases ARNT homodimer transactivation potential. 2002. Cell Biol Toxicol. 18(2):109-20. National Institute of Environmental Health Sciences Petrulis JR. Perdew GH. Monitoring nuclear import with GFP-variant fusion proteins in digitonin-permeabilized cells. 2001 Oct. Biotechniques. 31(4):772-5. National Institute of Environmental Health Sciences Kumar MB. Ramadoss P. Reen RK. Vanden Heuvel JP. Perdew GH. The Q-rich subdomain of the human Ah receptor transactivation domain is required for dioxin-mediated transcriptional activity. 2001 Nov 9. J Biol Chem. 276(45):42302-10. National Institute of Environmental Health Sciences Levine SL. Perdew GH. Aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) activity is unaltered by phosphorylation of a periodicity/ARNT/single-minded (PAS)-region serine residue. 2001 Mar. Mol Pharmacol. 59(3):557-66. National Institute of Environmental Health Sciences Meyer BK. Petrulis JR. Perdew GH. Aryl hydrocarbon (Ah) receptor levels are selectively modulated by hsp90-associated immunophilin homolog XAP2. 2000 Jul. Cell Stress Chaperones. 5(3):243-54. National Institute of Environmental Health Sciences Petrulis JR. Hord NG. Perdew GH. Subcellular localization of the aryl hydrocarbon receptor is modulated by the immunophilin homolog hepatitis B virus X-associated protein 2. 2000 Dec 1. J Biol Chem. 275(48):37448-53. National Institute of Environmental Health Sciences Levine SL. Petrulis JR. Dubil A. Perdew GH. A tetratricopeptide repeat half-site in the aryl hydrocarbon receptor is important for DNA binding and trans-activation potential. 2000 Dec. Mol Pharmacol. 58(6):1517-24. National Institute of Environmental Health Sciences Long WP. Perdew GH. Lack of an absolute requirement for the native aryl hydrocarbon receptor (AhR) and AhR nuclear translocator transactivation domains in protein kinase C-mediated modulation of the AhR pathway. 1999 Nov 15. Arch Biochem Biophys. 371(2):246-59. National Institute of Environmental Health Sciences Meyer BK. Perdew GH. Characterization of the AhR-hsp90-XAP2 core complex and the role of the immunophilin-related protein XAP2 in AhR stabilization. 1999 Jul 13. Biochemistry. 38(28):8907-17. National Institute of Environmental Health Sciences Kumar MB. Tarpey RW. Perdew GH. Differential recruitment of coactivator RIP140 by Ah and estrogen receptors. Absence of a role for LXXLL motifs. 1999 Aug 6. J Biol Chem. 274(32):22155-64. National Institute of Environmental Health Sciences Long WP. Chen X. Perdew GH. Protein kinase C modulates aryl hydrocarbon receptor nuclear translocator protein-mediated transactivation potential in a dimer context. 1999 Apr 30. J Biol Chem. 274(18):12391-400. National Institute of Environmental Health Sciences Kumar MB. Perdew GH. Nuclear receptor coactivator SRC-1 interacts with the Q-rich subdomain of the AhR and modulates its transactivation potential. 1999. Gene Expr. 8(5-6):273-86. National Institute of Environmental Health Sciences Meyer BK. Pray-Grant MG. Vanden Heuvel JP. Perdew GH. Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity. 1998 Feb. Mol Cell Biol. 18(2):978-88. National Institute of Environmental Health Sciences Long WP. Pray-Grant M. Tsai JC. Perdew GH. Protein kinase C activity is required for aryl hydrocarbon receptor pathway-mediated signal transduction. 1998 Apr. Mol Pharmacol. 53(4):691-700. National Institute of Environmental Health Sciences Perdew GH. Wiegand H. Vanden Heuvel JP. Mitchell C. Singh SS. A 50 kilodalton protein associated with raf and pp60(v-src) protein kinases is a mammalian homolog of the cell cycle control protein cdc37. 1997 Mar 25. Biochemistry. 36(12):3600-7. Tsai JC. Perdew GH. Ah receptor nuclear translocator protein heterogeneity is altered after heterodimerization with the Ah receptor. 1997 Jul 22. Biochemistry. 36(29):9066-72. National Institute of Environmental Health Sciences Chen HS. Singh SS. Perdew GH. The Ah receptor is a sensitive target of geldanamycin-induced protein turnover. 1997 Dec 1. Arch Biochem Biophys. 348(1):190-8. National Institute of Environmental Health Sciences Singh SS. Hord NG. Perdew GH. Characterization of the activated form of the aryl hydrocarbon receptor in the nucleus of HeLa cells in the absence of exogenous ligand. 1996 May 1. Arch Biochem Biophys. 329(1):47-55. National Institute of Environmental Health Sciences Perdew GH. Bradfield CA. Mapping the 90 kDa heat shock protein binding region of the Ah receptor. 1996 Jun. Biochem Mol Biol Int. 39(3):589-93. National Institute of Environmental Health Sciences