Ian A. Simpson All publications ( 114 ) Zinnanti WJ. Lazovic J. Housman C. LaNoue K. O'Callaghan JP. Simpson I. Woontner M. Goodman SI. Connor JR. Jacobs RE. Cheng KC. Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I. 2007 Nov. J Clin Invest. 117(11):3258-70. Simpson IA. Carruthers A. Vannucci SJ. Supply and demand in cerebral energy metabolism: the role of nutrient transporters. 2007 Nov. J Cereb Blood Flow Metab. 27(11):1766-91. Fisher J. Devraj K. Ingram J. Slagle-Webb B. Madhankumar AB. Liu X. Klinger M. Simpson IA. Connor JR. Ferritin: a novel mechanism for delivery of iron to the brain and other organs. 2007 Aug. Am J Physiol Cell Physiol. 293(2):C641-9. Kumari R. Willing LB. Krady JK. Vannucci SJ. Simpson IA. Impaired wound healing after cerebral hypoxia-ischemia in the diabetic mouse. 2007 Apr. J Cereb Blood Flow Metab. 27(4):710-8. Antonetti DA. Barber AJ. Bronson SK. Freeman WM. Gardner TW. Jefferson LS. Kester M. Kimball SR. Krady JK. LaNoue KF. Norbury CC. Quinn PG. Sandirasegarane L. Simpson IA. JDRF Diabetic Retinopathy Center Group. Diabetic retinopathy: seeing beyond glucose-induced microvascular disease. 2006 Sep. Diabetes. 55(9):2401-11. National Eye Institute Sambu N. Wald DS. Seddon M. Simpson IA. Undertreatment of coronary heart disease in patients undergoing coronary artery bypass surgery. 2006 May. Heart. 92(5):697-8. Ola MS. Berkich DA. Xu Y. King MT. Gardner TW. Simpson I. LaNoue KF. Analysis of glucose metabolism in diabetic rat retinas. 2006 Jun. Am J Physiol Endocrinol Metab. 290(6):E1057-67. Hawkins RA. O'Kane RL. Simpson IA. Viña JR. Structure of the blood-brain barrier and its role in the transport of amino acids. 2006 Jan. J Nutr. 136(1 Suppl):218S-26S. National Institute of Neurological Disorders and Stroke Basile M. Lin R. Kabbani N. Karpa K. Kilimann M. Simpson I. Kester M. Paralemmin interacts with D3 dopamine receptors: implications for membrane localization and cAMP signaling. 2006 Feb 1. Arch Biochem Biophys. 446(1):60-8. Hawkins RA. Simpson IA. Mokashi A. Viña JR. Pyroglutamate stimulates Na+ -dependent glutamate transport across the blood-brain barrier. 2006 Aug 7. FEBS Lett. 580(18):4382-6. National Institute of Neurological Disorders and Stroke O'Kane RL. Viña JR. Simpson I. Zaragozá R. Mokashi A. Hawkins RA. Cationic amino acid transport across the blood-brain barrier is mediated exclusively by system y+. 2006 Aug. Am J Physiol Endocrinol Metab. 291(2):E412-9. National Institute of Neurological Disorders and Stroke Nehlig A. Rudolf G. Leroy C. Rigoulot MA. Simpson IA. Vannucci SJ. Pentylenetetrazol-induced status epilepticus up-regulates the expression of glucose transporter mRNAs but not proteins in the immature rat brain. 2006 Apr 12. Brain Res. 1082(1):32-42. National Institute of Child Health and Human Development Hawkins RA. Mokashi A. Simpson IA. An active transport system in the blood-brain barrier may reduce levodopa availability. 2005 Sep. Exp Neurol. 195(1):267-71. National Institute of Neurological Disorders and Stroke Alharbi KK. Aldahmesh MA. Spanakis E. Haddad L. Whittall RA. Chen XH. Rassoulian H. Smith MJ. Sillibourne J. Ball NJ. Graham NJ. Briggs PJ. Simpson IA. Phillips DI. Lawlor DA. Ye S. Humphries SE. Cooper C. Smith GD. Ebrahim S. Eccles DM. Day IN. Mutation scanning by meltMADGE: validations using BRCA1 and LDLR, and demonstration of the potential to identify severe, moderate, silent, rare, and paucimorphic mutations in the general population. 2005 Jul. Genome Res. 15(7):967-77. Zhang F. Vannucci SJ. Philp NJ. Simpson IA. Monocarboxylate transporter expression in the spontaneous hypertensive rat: effect of stroke. 2005 Jan 1-15. J Neurosci Res. 79(1-2):139-45. O'Kane RL. Viña JR. Simpson I. Hawkins RA. Na+ -dependent neutral amino acid transporters A, ASC, and N of the blood-brain barrier: mechanisms for neutral amino acid removal. 2004 Oct. Am J Physiol Endocrinol Metab. 287(4):E622-9. National Institute of Neurological Disorders and Stroke Burdo JR. Simpson IA. Menzies S. Beard J. Connor JR. Regulation of the profile of iron-management proteins in brain microvasculature. 2004 Jan. J Cereb Blood Flow Metab. 24(1):67-74. Zhang L. Nair A. Krady K. Corpe C. Bonneau RH. Simpson IA. Vannucci SJ. Estrogen stimulates microglia and brain recovery from hypoxia-ischemia in normoglycemic but not diabetic female mice. 2004 Jan. J Clin Invest. 113(1):85-95. Skaria B. Kalra P. Simpson IA. Septic emboli from aortic valve endocarditis. 2004 Aug. Heart. 90(8):865. Reiter CE. Sandirasegarane L. Wolpert EB. Klinger M. Simpson IA. Barber AJ. Antonetti DA. Kester M. Gardner TW. Characterization of insulin signaling in rat retina in vivo and ex vivo. 2003 Oct. Am J Physiol Endocrinol Metab. 285(4):E763-74. National Institute of General Medical Sciences Vannucci SJ. Simpson IA. Developmental switch in brain nutrient transporter expression in the rat. 2003 Nov. Am J Physiol Endocrinol Metab. 285(5):E1127-34. National Institute of Child Health and Human Development Simpson IA. Vannucci SJ. Glucose transport into brain: effects of hypoglycemia. 2002 Oct. Diabetes Nutr Metab. 15(5):281-4; discussion 284. Corpe CP. Bovelander FJ. Munoz CM. Hoekstra JH. Simpson IA. Kwon O. Levine M. Burant CF. Cloning and functional characterization of the mouse fructose transporter, GLUT5. 2002 Jun 7. Biochim Biophys Acta. 1576(1-2):191-7. National Institute of Diabetes and Digestive and Kidney Diseases Betts TR. Simpson IA. Inhibition of temporary pacing by a mobile phone. 2002 Feb. Heart. 87(2):130. Dwyer DS. Vannucci SJ. Simpson IA. Expression, regulation, and functional role of glucose transporters (GLUTs) in brain. 2002. Int Rev Neurobiol. 51:159-88. Vannucci SJ. Willing LB. Goto S. Alkayed NJ. Brucklacher RM. Wood TL. Towfighi J. Hurn PD. Simpson IA. Experimental stroke in the female diabetic, db/db, mouse. 2001 Jan. J Cereb Blood Flow Metab. 21(1):52-60. Wong Y. Rodwell A. Dawkins S. Livesey SA. Simpson IA. Sex differences in investigation results and treatment in subjects referred for investigation of chest pain. 2001 Feb. Heart. 85(2):149-52. Burdo JR. Menzies SL. Simpson IA. Garrick LM. Garrick MD. Dolan KG. Haile DJ. Beard JL. Connor JR. Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat. 2001 Dec 15. J Neurosci Res. 66(6):1198-207. National Institute of Diabetes and Digestive and Kidney Diseases National Heart, Lung, and Blood Institute National Institute of Neurological Disorders and Stroke Vannucci SJ. Simpson IA. Synopsis of the workshop entitled "Is lactate a nutrient for neurons" held at the Brain Energy Meeting in Trondheim, Norway. 2001 Dec 1. J Neurosci Res. 66(5):821-3. Simpson IA. Vannucci SJ. DeJoseph MR. Hawkins RA. Glucose transporter asymmetries in the bovine blood-brain barrier. 2001 Apr 20. J Biol Chem. 276(16):12725-9. National Institute of Neurological Disorders and Stroke Rumsey SC. Daruwala R. Al-Hasani H. Zarnowski MJ. Simpson IA. Levine M. Dehydroascorbic acid transport by GLUT4 in Xenopus oocytes and isolated rat adipocytes. 2000 Sep 8. J Biol Chem. 275(36):28246-53. Calver AL. Blows LJ. Harmer S. Dawkins KD. Gray HH. Morgan JH. Simpson IA. Clopidogrel for prevention of major cardiac events after coronary stent implantation: 30-day and 6-month results in patients with smaller stents. 2000 Sep. Am Heart J. 140(3):483-91. Strike PC. Jones RA. Simpson IA. An unusual atrial mass. 2000 Nov. Clin Cardiol. 23(11):862-4. Coleman JE. Mansfield RJ. Simpson IA. Myocardial infarction and sub-acute ventricular rupture: successful outcome in two cases. 2000 May 31. Int J Cardiol. 73(3):285-7. Koehler-Stec EM. Li K. Maher F. Vannucci SJ. Smith CB. Simpson IA. Cerebral glucose utilization and glucose transporter expression: response to water deprivation and restoration. 2000 Jan. J Cereb Blood Flow Metab. 20(1):192-200. Vannucci SJ. Rutherford T. Wilkie MB. Simpson IA. Lauder JM. Prenatal expression of the GLUT4 glucose transporter in the mouse. 2000. Dev Neurosci. 22(4):274-82. Liu D. Smith CL. Barone FC. Ellison JA. Lysko PG. Li K. Simpson IA. Astrocytic demise precedes delayed neuronal death in focal ischemic rat brain. 1999 May 7. Brain Res Mol Brain Res. 68(1-2):29-41. Haspel HC. Stephenson KN. Davies-Hill T. El-Barbary A. Lobo JF. Croxen RL. Mougrabi W. Koehler-Stec EM. Fenstermacher JD. Simpson IA. Effects of barbiturates on facilitative glucose transporters are pharmacologically specific and isoform selective. 1999 May 1. J Membr Biol. 169(1):45-53. National Institute of Neurological Disorders and Stroke Simpson IA. Appel NM. Hokari M. Oki J. Holman GD. Maher F. Koehler-Stec EM. Vannucci SJ. Smith QR. Blood-brain barrier glucose transporter: effects of hypo- and hyperglycemia revisited. 1999 Jan. J Neurochem. 72(1):238-47. Mankowski JL. Queen SE. Kirstein LM. Spelman JP. Laterra J. Simpson IA. Adams RJ. Clements JE. Zink MC. Alterations in blood-brain barrier glucose transport in SIV-infected macaques. 1999 Dec. J Neurovirol. 5(6):695-702. National Institute of Neurological Disorders and Stroke National Center for Research Resources Koehler-Stec EM. Simpson IA. Vannucci SJ. Landschulz KT. Landschulz WH. Monocarboxylate transporter expression in mouse brain. 1998 Sep. Am J Physiol. 275(3 Pt 1):E516-24. National Institute of Child Health and Human Development Vannucci SJ. Reinhart R. Maher F. Bondy CA. Lee WH. Vannucci RC. Simpson IA. Alterations in GLUT1 and GLUT3 glucose transporter gene expression following unilateral hypoxia-ischemia in the immature rat brain. 1998 May 15. Brain Res Dev Brain Res. 107(2):255-64. National Institute of Child Health and Human Development Malide D. Davies-Hill TM. Levine M. Simpson IA. Distinct localization of GLUT-1, -3, and -5 in human monocyte-derived macrophages: effects of cell activation. 1998 Mar. Am J Physiol. 274(3 Pt 1):E516-26. Vannucci SJ. Koehler-Stec EM. Li K. Reynolds TH. Clark R. Simpson IA. GLUT4 glucose transporter expression in rodent brain: effect of diabetes. 1998 Jun 22. Brain Res. 797(1):1-11. Vannucci SJ. Clark RR. Koehler-Stec E. Li K. Smith CB. Davies P. Maher F. Simpson IA. Glucose transporter expression in brain: relationship to cerebral glucose utilization. 1998. Dev Neurosci. 20(4-5):369-79. National Institute of Child Health and Human Development Vannucci SJ. Maher F. Simpson IA. Glucose transporter proteins in brain: delivery of glucose to neurons and glia. 1997 Sep. Glia. 21(1):2-21. National Institute of Child Health and Human Development Payne J. Maher F. Simpson I. Mattice L. Davies P. Glucose transporter Glut 5 expression in microglial cells. 1997 Nov. Glia. 21(3):327-31. Public Health Service National Institute of Mental Health Kol S. Ben-Shlomo I. Ruutiainen K. Ando M. Davies-Hill TM. Rohan RM. Simpson IA. Adashi EY. The midcycle increase in ovarian glucose uptake is associated with enhanced expression of glucose transporter 3. Possible role for interleukin-1, a putative intermediary in the ovulatory process. 1997 May 1. J Clin Invest. 99(9):2274-83. National Institute of Child Health and Human Development Rumsey SC. Kwon O. Xu GW. Burant CF. Simpson I. Levine M. Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid. 1997 Jul 25. J Biol Chem. 272(30):18982-9. Vannucci SJ. Gibbs EM. Simpson IA. Glucose utilization and glucose transporter proteins GLUT-1 and GLUT-3 in brains of diabetic (db/db) mice. 1997 Feb. Am J Physiol. 272(2 Pt 1):E267-74. Sorbara LR. Davies-Hill TM. Koehler-Stec EM. Vannucci SJ. Horne MK. Simpson IA. Thrombin-induced translocation of GLUT3 glucose transporters in human platelets. 1997 Dec 1. Biochem J. 328 ( Pt 2):511-6. Sorbara LR. Maldarelli F. Chamoun G. Schilling B. Chokekijcahi S. Staudt L. Mitsuya H. Simpson IA. Zeichner SL. Human immunodeficiency virus type 1 infection of H9 cells induces increased glucose transporter expression. 1996 Oct. J Virol. 70(10):7275-9. Maher F. Davies-Hill TM. Simpson IA. Substrate specificity and kinetic parameters of GLUT3 in rat cerebellar granule neurons. 1996 May 1. Biochem J. 315 ( Pt 3):827-31. Vannucci SJ. Maher F. Koehler E. Simpson IA. Altered expression of GLUT-1 and GLUT-3 glucose transporters in neurohypophysis of water-deprived or diabetic rats. 1994 Oct. Am J Physiol. 267(4 Pt 1):E605-11. National Institute of Child Health and Human Development Maher F. Vannucci SJ. Simpson IA. Glucose transporter proteins in brain. 1994 Oct. FASEB J. 8(13):1003-11. Kraemer FB. Sather SA. Park B. Sztalryd C. Natu V. May K. Nishimura H. Simpson I. Cooper AD. Cushman SW. Low density lipoprotein receptors in rat adipose cells: subcellular localization and regulation by insulin. 1994 Oct. J Lipid Res. 35(10):1760-72. National Institute of Diabetes and Digestive and Kidney Diseases National Heart, Lung, and Blood Institute Simpson IA. Davies P. Reduced glucose transporter concentrations in brains of patients with Alzheimer's disease. 1994 Nov. Ann Neurol. 36(5):800-1. Simpson IA. Chundu KR. Davies-Hill T. Honer WG. Davies P. Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease. 1994 May. Ann Neurol. 35(5):546-51. National Institute on Aging National Institute of Mental Health Maher F. Simpson IA. The GLUT3 glucose transporter is the predominant isoform in primary cultured neurons: assessment by biosynthetic and photoaffinity labelling. 1994 Jul 15. Biochem J. 301 ( Pt 2):379-84. Nishimura H. Simpson IA. Staurosporine inhibits phorbol 12-myristate 13-acetate- and insulin-stimulated translocation of GLUT1 and GLUT4 glucose transporters in rat adipose cells. 1994 Aug 15. Biochem J. 302 ( Pt 1):271-7. Maher F. Simpson IA. Modulation of expression of glucose transporters GLUT3 and GLUT1 by potassium and N-methyl-D-aspartate in cultured cerebellar granule neurons. 1994 Aug. Mol Cell Neurosci. 5(4):369-75. Simpson IA. Vannucci SJ. Maher F. Glucose transporters in mammalian brain. 1994 Aug. Biochem Soc Trans. 22(3):671-5. Nishimura H. Zarnowski MJ. Simpson IA. Glucose transporter recycling in rat adipose cells. Effects of potassium depletion. 1993 Sep 15. J Biol Chem. 268(26):19246-53. Sutkowski EM. Maher F. Laurenza A. Simpson IA. Seamon KB. Interaction of 7-bromoacetyl-7-desacetylforskolin, and alkylating derivative of forskolin, with bovine brain adenylyl cyclase and human erythrocyte glucose transporter. 1993 Mar 9. Biochemistry. 32(9):2415-22. Maher F. Vannucci SJ. Simpson IA. Glucose transporter isoforms in brain: absence of GLUT3 from the blood-brain barrier. 1993 Mar. J Cereb Blood Flow Metab. 13(2):342-5. Satoh S. Nishimura H. Clark AE. Kozka IJ. Vannucci SJ. Simpson IA. Quon MJ. Cushman SW. Holman GD. Use of bismannose photolabel to elucidate insulin-regulated GLUT4 subcellular trafficking kinetics in rat adipose cells. Evidence that exocytosis is a critical site of hormone action. 1993 Aug 25. J Biol Chem. 268(24):17820-9. Nishimura H. Pallardo FV. Seidner GA. Vannucci S. Simpson IA. Birnbaum MJ. Kinetics of GLUT1 and GLUT4 glucose transporters expressed in Xenopus oocytes. 1993 Apr 25. J Biol Chem. 268(12):8514-20. National Institute of Diabetes and Digestive and Kidney Diseases Maher F. Simpson IA. Vannucci SJ. Alterations in brain glucose transporter proteins, GLUT1 and GLUT3, in streptozotocin diabetic rats. 1993. Adv Exp Med Biol. 331:9-12. Vannucci SJ. Nishimura H. Satoh S. Cushman SW. Holman GD. Simpson IA. Cell surface accessibility of GLUT4 glucose transporters in insulin-stimulated rat adipose cells. Modulation by isoprenaline and adenosine. 1992 Nov 15. Biochem J. 288 ( Pt 1):325-30. Robbins JD. Appel NM. Laurenza A. Simpson IA. De Souza EB. Seamon KB. Differential identification and localization of adenylyl cyclase and glucose transporter in brain using iodinated derivatives of forskolin. 1992 May 22. Brain Res. 581(1):148-52. Goto Y. Sumida Y. Flanagan JE. Robinson FW. Simpson IA. Cushman SW. Kono T. Effects of fluorescein isothiocyanate on insulin actions in rat adipocytes. 1992 Mar. Arch Biochem Biophys. 293(2):224-30. National Institute of Diabetes and Digestive and Kidney Diseases Bilan PJ. Mitsumoto Y. Maher F. Simpson IA. Klip A. Detection of the GLUT3 facilitative glucose transporter in rat L6 muscle cells: regulation by cellular differentiation, insulin and insulin-like growth factor-I. 1992 Jul 31. Biochem Biophys Res Commun. 186(2):1129-37. Maher F. Vannucci S. Takeda J. Simpson IA. Expression of mouse-GLUT3 and human-GLUT3 glucose transporter proteins in brain. 1992 Jan 31. Biochem Biophys Res Commun. 182(2):703-11. Honnor RC. Naghshineh S. Cushman SW. Wolff J. Simpson IA. Londos C. Cholera and pertussis toxins modify regulation of glucose transport activity in rat adipose cells: evidence for mediation of a cAMP-independent process by G-proteins. 1992 Jan. Cell Signal. 4(1):87-98. Saltis J. Habberfield AD. Egan JJ. Londos C. Simpson IA. Cushman SW. Role of protein kinase C in the regulation of glucose transport in the rat adipose cell. Translocation of glucose transporters without stimulation of glucose transport activity. 1991 Jan 5. J Biol Chem. 266(1):261-7. Nishimura H. Saltis J. Habberfield AD. Garty NB. Greenberg AS. Cushman SW. Londos C. Simpson IA. Phosphorylation state of the GLUT4 isoform of the glucose transporter in subfractions of the rat adipose cell: effects of insulin, adenosine, and isoproterenol. 1991 Dec 15. Proc Natl Acad Sci U S A. 88(24):11500-4. Weber TM. Joost HG. Kuroda M. Cushman SW. Simpson IA. Subcellular distribution and phosphorylation state of insulin receptors from insulin- and isoproterenol-treated rat adipose cells. 1991. Cell Signal. 3(1):51-8. Holman GD. Kozka IJ. Clark AE. Flower CJ. Saltis J. Habberfield AD. Simpson IA. Cushman SW. Cell surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester. 1990 Oct 25. J Biol Chem. 265(30):18172-9. Egan JJ. Saltis J. Wek SA. Simpson IA. Londos C. Insulin, oxytocin, and vasopressin stimulate protein kinase C activity in adipocyte plasma membranes. 1990 Feb. Proc Natl Acad Sci U S A. 87(3):1052-6. National Institute of Diabetes and Digestive and Kidney Diseases Simpson IA. Cushman SW. Egan JJ. Habberfield AD. Londos C. Nishimura H. Saltis J. Hormonal regulation of glucose transport in rat adipose cells. 1990 Dec. Biochem Soc Trans. 18(6):1123-5. Werner H. Raizada MK. Mudd LM. Foyt HL. Simpson IA. Roberts CT. LeRoith D. Regulation of rat brain/HepG2 glucose transporter gene expression by insulin and insulin-like growth factor-I in primary cultures of neuronal and glial cells. 1989 Jul. Endocrinology. 125(1):314-20. Lönnroth P. Appell KC. Wesslau C. Cushman SW. Simpson IA. Smith U. Insulin-induced subcellular redistribution of insulin-like growth factor II receptors in the rat adipose cell. Counterregulatory effects of isoproterenol, adenosine, and cAMP analogues. 1988 Oct 25. J Biol Chem. 263(30):15386-91. Appell KC. Simpson IA. Cushman SW. Characterization of the stimulatory action of insulin on insulin-like growth factor II binding to rat adipose cells. Differences in the mechanism of insulin action on insulin-like growth factor II receptors and glucose transporters. 1988 Aug 5. J Biol Chem. 263(22):10824-9. Kahn BB. Simpson IA. Cushman SW. Divergent mechanisms for the insulin resistant and hyperresponsive glucose transport in adipose cells from fasted and refed rats. Alterations in both glucose transporter number and intrinsic activity. 1988 Aug. J Clin Invest. 82(2):691-9. Joost HG. Habberfield AD. Simpson IA. Laurenza A. Seamon KB. Activation of adenylate cyclase and inhibition of glucose transport in rat adipocytes by forskolin analogues: structural determinants for distinct sites of action. 1988 Apr. Mol Pharmacol. 33(4):449-53. Kuroda M. Honnor RC. Cushman SW. Londos C. Simpson IA. Regulation of insulin-stimulated glucose transport in the isolated rat adipocyte. cAMP-independent effects of lipolytic and antilipolytic agents. 1987 Jan 5. J Biol Chem. 262(1):245-53. Joost HG. Weber TM. Cushman SW. Simpson IA. Activity and phosphorylation state of glucose transporters in plasma membranes from insulin-, isoproterenol-, and phorbol ester-treated rat adipose cells. 1987 Aug 15. J Biol Chem. 262(23):11261-7. Horuk R. Matthaei S. Olefsky JM. Baly DL. Cushman SW. Simpson IA. Biochemical and functional heterogeneity of rat adipocyte glucose transporters. 1986 Feb 5. J Biol Chem. 261(4):1823-8. National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases Karnieli E. Chernow B. Hissin PJ. Simpson IA. Foley JE. Insulin stimulates glucose transport in isolated human adipose cells through a translocation of intracellular glucose transporters to the plasma membrane: a preliminary report. 1986 Dec. Horm Metab Res. 18(12):867-8. National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases Joost HG. Weber TM. Cushman SW. Simpson IA. Insulin-stimulated glucose transport in rat adipose cells. Modulation of transporter intrinsic activity by isoproterenol and adenosine. 1986 Aug 5. J Biol Chem. 261(22):10033-6. Simpson IA. Cushman SW. Hormonal regulation of mammalian glucose transport. 1986. Annu Rev Biochem. 55:1059-89. Hedo JA. Simpson IA. Biosynthesis of the insulin receptor in rat adipose cells. Intracellular processing of the Mr-190 000 pro-receptor. 1985 Nov 15. Biochem J. 232(1):71-8. Cushman SW. Simpson IA. Integral membrane protein translocations in the mechanism of insulin action. 1985. Biochem Soc Symp. 50:127-49. Hedo JA. Simpson IA. Internalization of insulin receptors in the isolated rat adipose cell. Demonstration of the vectorial disposition of receptor subunits. 1984 Sep 10. J Biol Chem. 259(17):11083-9. Cushman SW. Wardzala LJ. Simpson IA. Karnieli E. Hissin PJ. Wheeler TJ. Hinkle PC. Salans LB. Insulin-induced translocation of intracellular glucose transporters in the isolated rat adipose cell. 1984 May 15. Fed Proc. 43(8):2251-5. National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases National Cancer Institute Simpson IA. Hedo JA. Insulin receptor phosphorylation may not be a prerequisite for acute insulin action. 1984 Mar 23. Science. 223(4642):1301-4. Smith U. Kuroda M. Simpson IA. Counter-regulation of insulin-stimulated glucose transport by catecholamines in the isolated rat adipose cell. 1984 Jul 25. J Biol Chem. 259(14):8758-63. Wardzala LJ. Simpson IA. Rechler MM. Cushman SW. Potential mechanism of the stimulatory action of insulin on insulin-like growth factor II binding to the isolated rat adipose cell. Apparent redistribution of receptors cycling between a large intracellular pool and the plasma membrane. 1984 Jul 10. J Biol Chem. 259(13):8378-83. Simpson IA. Hedo JA. Cushman SW. Insulin-induced internalization of the insulin receptor in the isolated rat adipose cell. Detection of both major receptor subunits following their biosynthetic labeling in culture. 1984 Jan. Diabetes. 33(1):13-8. Sonne O. Simpson IA. Internalization of insulin and its receptor in the isolated rat adipose cell. Time-course and insulin concentration dependency. 1984 Aug 17. Biochim Biophys Acta. 804(4):404-13. Simpson IA. Yver DR. Hissin PJ. Wardzala LJ. Karnieli E. Salans LB. Cushman SW. Insulin-stimulated translocation of glucose transporters in the isolated rat adipose cells: characterization of subcellular fractions. 1983 Dec 19. Biochim Biophys Acta. 763(4):393-407. Wang CC. Sonne O. Hedo JA. Cushman SW. Simpson IA. Insulin-induced internalization of the insulin receptor in the isolated rat adipose cell. Detection of the internalized 138-kilodalton receptor subunit using a photoaffinity 125I-insulin. 1983 Apr 25. J Biol Chem. 258(8):5129-34. Hissin PJ. Foley JE. Wardzala LJ. Karnieli E. Simpson IA. Salans LB. Cushman SW. Mechanism of insulin-resistant glucose transport activity in the enlarged adipose cell of the aged, obese rat. 1982 Oct. J Clin Invest. 70(4):780-90. National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases Public Health Service Wheeler TJ. Simpson IA. Sogin DC. Hinkle PC. Cushman SW. Detection of the rat adipose cell glucose transporter with antibody against the human red cell glucose transporter. 1982 Mar 15. Biochem Biophys Res Commun. 105(1):89-95. National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases National Cancer Institute Hissin PJ. Karnieli E. Simpson IA. Salans LB. Cushman SW. A possible mechanism of insulin resistance in the rat adipose cell with high-fat/low-carbohydrate feeding. Depletion of intracellular glucose transport systems. 1982 Jul. Diabetes. 31(7):589-92. Simpson IA. Sonne O. A simple, rapid, and sensitive method for measuring protein concentration in subcellular membrane fractions prepared by sucrose density ultracentrifugation. 1982 Jan 15. Anal Biochem. 119(2):424-7. Karnieli E. Hissin PJ. Simpson IA. Salans LB. Cushman SW. A possible mechanism of insulin resistance in the rat adipose cell in streptozotocin-induced diabetes mellitus. Depletion of intracellular glucose transport systems. 1981 Sep. J Clin Invest. 68(3):811-4. Karnieli E. Zarnowski MJ. Hissin PJ. Simpson IA. Salans LB. Cushman SW. Insulin-stimulated translocation of glucose transport systems in the isolated rat adipose cell. Time course, reversal, insulin concentration dependency, and relationship to glucose transport activity. 1981 May 25. J Biol Chem. 256(10):4772-7. Cushman SW. Hissin PJ. Wardzala LJ. Foley JE. Simpson IA. Karnieli E. Salans LB. Mechanism of insulin-resistance in the adipose cell in the aging-rat model of obesity. 1981 Dec. Biochem Soc Trans. 9(6):518-22. Simpson IA. Pfeuffer T. Functional desensitisation of beta-adrenergic receptors of avian erythrocytes by catecholamines and adenosine 3',5'-phosphate. 1980 Oct. Eur J Biochem. 111(1):111-6. Simpson IA. Pfeuffer T. Modulation of beta-adrenergic agonist binding by guanylnucleotides in avian erythrocytes. 1980 Jun 16. FEBS Lett. 115(1):113-7. Simpson IA. Hollaway MR. Beard J. The subunit structure of rabbit skeletal-muscle phosphofructokinase and the amino acid sequence of the tryptic peptide containing the highly reactive thiol group. 1977 May 1. Biochem J. 163(2):309-16. Simpson IA. Hollaway MR. An investigation of the subunit structure of rabbit skeletal-muscle phosphofructokinase. 1976. Biochem Soc Trans. 4(1):85-7. Hall DE. Simpson IA. Crosbie GW. Growth of Pseudomonas reptilivora on N-methylglycines. 1971 Sep. Biochem J. 124(2):31P.