John P. Richie, Jr. All publications ( 59 ) Nichenametla SN. Ellison I. Calcagnotto A. Lazarus P. Muscat JE. Richie JP. Functional significance of the GAG trinucleotide-repeat polymorphism in the gene for the catalytic subunit of gamma-glutamylcysteine ligase. 2008 Sep 1. Free Radic Biol Med. 45(5):645-50. Muscat JE. Pittman B. Kleinman W. Lazarus P. Stellman SD. Richie JP. Comparison of CYP1A2 and NAT2 phenotypes between black and white smokers. 2008 Jul 25. Biochem Pharmacol. . Richie JP. Kleinman W. Marina P. Abraham P. Wynder EL. Muscat JE. Blood iron, glutathione, and micronutrient levels and the risk of oral cancer. 2008. Nutr Cancer. 60(4):474-82. Vogt BL. Richie JP. Glutathione depletion and recovery after acute ethanol administration in the aging mouse. 2007 May 15. Biochem Pharmacol. 73(10):1613-21. Richie JP. Komninou D. Albino AP. Induction of colon tumorigenesis by glutathione depletion in p53-knock-out mice. 2007 Jun. Int J Oncol. 30(6):1539-43. National Institute on Aging National Cancer Institute Huang Z. Komninou D. Kleinman W. Pinto JT. Gilhooly EM. Calcagnotto A. Richie JP. Enhanced levels of glutathione and protein glutathiolation in rat tongue epithelium during 4-NQO-induced carcinogenesis. 2007 Jan 4. Int J Cancer. . Gallagher CJ. Muscat JE. Hicks AN. Zheng Y. Dyer AM. Chase GA. Richie J. Lazarus P. The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer. 2007 Apr. Cancer Epidemiol Biomarkers Prev. 16(4):823-8. National Cancer Institute National Institute for Dental and Craniofacial Research Richie JP. Kleinman W. Desai DH. Das A. Amin SG. Pinto JT. El-Bayoumy K. The organoselenium compound 1,4-phenylenebis(methylene)selenocyanate inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorgenesis and enhances glutathione-related antioxidant levels in A/J mouse lung. 2006 Jun 10. Chem Biol Interact. 161(2):93-103. National Cancer Institute Komninou D. Leutzinger Y. Reddy BS. Richie JP. Methionine restriction inhibits colon carcinogenesis. 2006. Nutr Cancer. 54(2):202-8. Rundle AG. Orjuela M. Mooney L. Tang D. Kim M. Calcagnotto A. Richie JP. Perera F. Preliminary studies on the effect of moderate physical activity on blood levels of glutathione. 2005 Sep-Oct. Biomarkers. 10(5):390-400. National Cancer Institute National Center for Research Resources Chung FL. Komninou D. Zhang L. Nath R. Pan J. Amin S. Richie J. Glutathione depletion enhances the formation of endogenous cyclic DNA adducts derived from t-4-hydroxy-2-nonenal in rat liver. 2005 Jan. Chem Res Toxicol. 18(1):24-7. National Cancer Institute Muscat JE. Djordjevic MV. Colosimo S. Stellman SD. Richie JP. Racial differences in exposure and glucuronidation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). 2005 Apr 1. Cancer. 103(7):1420-6. National Cancer Institute Richie JP. Komninou D. Leutzinger Y. Kleinman W. Orentreich N. Malloy V. Zimmerman JA. Tissue glutathione and cysteine levels in methionine-restricted rats. 2004 Sep. Nutrition. 20(9):800-5. National Cancer Institute Muscat JE. Kleinman W. Colosimo S. Muir A. Lazarus P. Park J. Richie JP. Enhanced protein glutathiolation and oxidative stress in cigarette smokers. 2004 Feb 15. Free Radic Biol Med. 36(4):464-70. National Cancer Institute Kleinman WA. Komninou D. Leutzinger Y. Colosimo S. Cox J. Lang CA. Richie JP. Protein glutathiolation in human blood. 2003 Mar 1. Biochem Pharmacol. 65(5):741-6. National Cancer Institute Elahi A. Bendaly J. Zheng Z. Muscat JE. Richie JP. Schantz SP. Lazarus P. Detection of UGT1A10 polymorphisms and their association with orolaryngeal carcinoma risk. 2003 Aug 15. Cancer. 98(4):872-80. National Cancer Institute National Institute for Dental and Craniofacial Research Muscat JE. Chen SQ. Richie JP. Altorki NK. Citron M. Olson S. Neugut AI. Stellman SD. Risk of lung carcinoma among users of nonsteroidal antiinflammatory drugs. 2003 Apr 1. Cancer. 97(7):1732-6. Stellman SD. Chen Y. Muscat JE. Djordjevic MV. Richie JP. Lazarus P. Thompson S. Altorki N. Berwick M. Citron ML. Harlap S. Kaur TB. Neugut AI. Olson S. Travaline JM. Witorsch P. Zhang ZF. Lung cancer risk in white and black Americans. 2003 Apr. Ann Epidemiol. 13(4):294-302. National Cancer Institute Komninou D. Ayonote A. Richie JP. Rigas B. Insulin resistance and its contribution to colon carcinogenesis. 2003 Apr. Exp Biol Med (Maywood). 228(4):396-405. National Cancer Institute El-Bayoumy K. Richie JP. Boyiri T. Komninou D. Prokopczyk B. Trushin N. Kleinman W. Cox J. Pittman B. Colosimo S. Influence of selenium-enriched yeast supplementation on biomarkers of oxidative damage and hormone status in healthy adult males: a clinical pilot study. 2002 Nov. Cancer Epidemiol Biomarkers Prev. 11(11):1459-65. Public Health Service Muscat JE. Richie JP. Stellman SD. Mentholated cigarettes and smoking habits in whites and blacks. 2002 Dec. Tob Control. 11(4):368-71. National Cancer Institute Lang CA. Mills BJ. Lang HL. Liu MC. Usui WM. Richie J. Mastropaolo W. Murrell SA. High blood glutathione levels accompany excellent physical and mental health in women ages 60 to 103 years. 2002 Dec. J Lab Clin Med. 140(6):413-7. Hurt RD. Croghan GA. Wolter TD. Croghan IT. Offord KP. Williams GM. Djordjevic MV. Richie JP. Jeffrey AM. Does smoking reduction result in reduction of biomarkers associated with harm? A pilot study using a nicotine inhaler. 2000 Nov. Nicotine Tob Res. 2(4):327-36. Kaur TB. Travaline JM. Gaughan JP. Richie JP. Stellman SD. Lazarus P. Role of polymorphisms in codons 143 and 160 of the O6-alkylguanine DNA alkyltransferase gene in lung cancer risk. 2000 Mar. Cancer Epidemiol Biomarkers Prev. 9(3):339-42. National Cancer Institute National Institute for Dental and Craniofacial Research Park LY. Muscat JE. Kaur T. Schantz SP. Stern JC. Richie JP. Lazarus P. Comparison of GSTM polymorphisms and risk for oral cancer between African-Americans and Caucasians. 2000 Mar. Pharmacogenetics. 10(2):123-31. National Cancer Institute National Institute for Dental and Craniofacial Research Kleinman WA. Richie JP. Status of glutathione and other thiols and disulfides in human plasma. 2000 Jul 1. Biochem Pharmacol. 60(1):19-29. National Institute on Aging National Cancer Institute Chen TS. Richie JP. Nagasawa HT. Lang CA. Glutathione monoethyl ester protects against glutathione deficiencies due to aging and acetaminophen in mice. 2000 Dec 1. Mech Ageing Dev. 120(1-3):127-39. Lazarus P. Sheikh SN. Ren Q. Schantz SP. Stern JC. Richie JP. Park JY. p53, but not p16 mutations in oral squamous cell carcinomas are associated with specific CYP1A1 and GSTM1 polymorphic genotypes and patient tobacco use. 1998 Mar. Carcinogenesis. 19(3):509-14. National Cancer Institute National Institute for Dental and Craniofacial Research Whysner J. Steward RE. Chen D. Conaway CC. Verna LK. Richie JP. Ali N. Williams GM. Formation of 8-oxodeoxyguanosine in brain DNA of rats exposed to acrylonitrile. 1998 Jun. Arch Toxicol. 72(7):429-38. Zhao Z. Khachik F. Richie JP. Cohen LA. Lycopene uptake and tissue disposition in male and female rats. 1998 Jun. Proc Soc Exp Biol Med. 218(2):109-14. Muscat JE. Stellman SD. Richie JP. Wynder EL. Lung cancer risk and workplace exposures in black men and women. 1998 Feb. Environ Res. 76(2):78-84. National Cancer Institute Richie JP. Carmella SG. Muscat JE. Scott DG. Akerkar SA. Hecht SS. Differences in the urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in black and white smokers. 1997 Oct. Cancer Epidemiol Biomarkers Prev. 6(10):783-90. National Cancer Institute Park JY. Muscat JE. Ren Q. Schantz SP. Harwick RD. Stern JC. Pike V. Richie JP. Lazarus P. CYP1A1 and GSTM1 polymorphisms and oral cancer risk. 1997 Oct. Cancer Epidemiol Biomarkers Prev. 6(10):791-7. National Cancer Institute Nath RG. Ocando JE. Richie JP. Chung FL. Effect of glutathione depletion on exocyclic adduct levels in the liver DNA of F344 rats. 1997 Nov. Chem Res Toxicol. 10(11):1250-3. National Cancer Institute El-Bayoumy K. Chung FL. Richie J. Reddy BS. Cohen L. Weisburger J. Wynder EL. Dietary control of cancer. 1997 Nov. Proc Soc Exp Biol Med. 216(2):211-23. National Cancer Institute Muscat JE. Richie JP. Thompson S. Wynder EL. Gender differences in smoking and risk for oral cancer. 1996 Nov 15. Cancer Res. 56(22):5192-7. National Cancer Institute National Institute for Dental and Craniofacial Research Richie JP. Abraham P. Leutzinger Y. Long-term stability of blood glutathione and cysteine in humans. 1996 Jul. Clin Chem. 42(7):1100-5. National Institute for Dental and Craniofacial Research Richie JP. Skowronski L. Abraham P. Leutzinger Y. Blood glutathione concentrations in a large-scale human study. 1996 Jan. Clin Chem. 42(1):64-70. National Institute for Dental and Craniofacial Research Lazarus P. Stern J. Zwiebel N. Fair A. Richie JP. Schantz S. Relationship between p53 mutation incidence in oral cavity squamous cell carcinomas and patient tobacco use. 1996 Apr. Carcinogenesis. 17(4):733-9. National Cancer Institute National Institute for Dental and Craniofacial Research Carmella SG. Akerkar SA. Richie JP. Hecht SS. Intraindividual and interindividual differences in metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers' urine. 1995 Sep. Cancer Epidemiol Biomarkers Prev. 4(6):635-42. National Cancer Institute Kleinman WA. Richie JP. Determination of thiols and disulfides using high-performance liquid chromatography with electrochemical detection. 1995 Oct 6. J Chromatogr B Biomed Appl. 672(1):73-80. National Institute for Dental and Craniofacial Research Lazarus P. Garewal HS. Sciubba J. Zwiebel N. Calcagnotto A. Fair A. Schaefer S. Richie JP. A low incidence of p53 mutations in pre-malignant lesions of the oral cavity from non-tobacco users. 1995 Feb 8. Int J Cancer. 60(4):458-63. National Institute for Dental and Craniofacial Research Hecht SS. Chung FL. Richie JP. Akerkar SA. Borukhova A. Skowronski L. Carmella SG. Effects of watercress consumption on metabolism of a tobacco-specific lung carcinogen in smokers. 1995 Dec. Cancer Epidemiol Biomarkers Prev. 4(8):877-84. National Cancer Institute Mills BJ. Richie JP. Lang CA. Glutathione disulfide variability in normal human blood. 1994 Oct. Anal Biochem. 222(1):95-101. Sohn OS. Surace A. Fiala ES. Richie JP. Colosimo S. Zang E. Weisburger JH. Effects of green and black tea on hepatic xenobiotic metabolizing systems in the male F344 rat. 1994 Feb. Xenobiotica. 24(2):119-27. National Cancer Institute Richie JP. Leutzinger Y. Parthasarathy S. Malloy V. Orentreich N. Zimmerman JA. Methionine restriction increases blood glutathione and longevity in F344 rats. 1994 Dec. FASEB J. 8(15):1302-7. Vogt BL. Richie JP. Fasting-induced depletion of glutathione in the aging mouse. 1993 Jul 20. Biochem Pharmacol. 46(2):257-63. National Institute on Alcohol Abuse and Alcoholism Richie JP. The role of glutathione in aging and cancer. 1992 Sep-Dec. Exp Gerontol. 27(5-6):615-26. Richie JP. Lang CA. Chen TS. Acetaminophen-induced depletion of glutathione and cysteine in the aging mouse kidney. 1992 Jul 7. Biochem Pharmacol. 44(1):129-35. Chen TS. Richie JP. Lang CA. Life span profiles of glutathione and acetaminophen detoxification. 1990 Nov-Dec. Drug Metab Dispos. 18(6):882-7. Mills BJ. Richie JP. Lang CA. Sample processing alters glutathione and cysteine values in blood. 1990 Feb 1. Anal Biochem. 184(2):263-7. Chen TS. Richie JP. Lang CA. The effect of aging on glutathione and cysteine levels in different regions of the mouse brain. 1989 Apr. Proc Soc Exp Biol Med. 190(4):399-402. Richie JP. Lang CA. A decrease in cysteine levels causes the glutathione deficiency of aging in the mosquito. 1988 Feb. Proc Soc Exp Biol Med. 187(2):235-40. Richie JP. Lang CA. The determination of glutathione, cyst(e)ine, and other thiols and disulfides in biological samples using high-performance liquid chromatography with dual electrochemical detection. 1987 May 15. Anal Biochem. 163(1):9-15. Richie JP. Mills BJ. Lang CA. Correction of a glutathione deficiency in the aging mosquito increases its longevity. 1987 Jan. Proc Soc Exp Biol Med. 184(1):113-7. Richie JP. Mills BJ. Lang CA. Dietary nordihydroguaiaretic acid increases the life span of the mosquito. 1986 Oct. Proc Soc Exp Biol Med. 183(1):81-5. Lang CA. Richie JP. Biogerontological precepts of Nathan Shock which influenced our aging research. 1986. Exp Gerontol. 21(4-5):235-9. Richie JP. Lang CA. Aging effects on acetaminophen toxicity and glutathione status in the mosquito. 1985 Jan-Feb. Drug Metab Dispos. 13(1):14-7. Richie JP. Mills BJ. Lang CA. The verification of a mammalian toxicant classification using a mosquito screening method. 1984 Dec. Fundam Appl Toxicol. 4(6):1029-35.