James W. Griffith
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Academic title Professor of Comparative Medicine
College College of Medicine
Campuses Penn State Milton S. Hershey Medical Center
Department Comparative Medicine
Graduate programs Lab Animal Medicine
Email Phone FAX
  jwg9@psu.edu
  717 531 8460
  717 531 5001
Educational background
  D.V.M., University of Missouri, 1976
Postdoctoral Training, University of Pennsylvania, 1981
Member of the American College of Veterinary Pathologists
Member of the American College of Laboratory Animal Medicine
Research interests
 

Veterinary Pathology, Comparative and Experimental Pathology, Pathobiology of mice

Research interests include the pathology of: spontaneous diseases of laboratory animals, genetically modified animal models of cancer, genetic studies of aging in mice, particulate induced pulmonary fibrosis, cardiovascular and respiratory pathology.

Areas of expertise
 
Pulmonary SurfactantsSelenium
TurtlesUveal Neoplasms
CardiomyopathiesOncogene Proteins
FentanylRats, Inbred Strains
Jugular VeinsMouth Mucosa
Sheep DiseasesPneumonia, Pneumococcal
AutoantigensRespiratory Tract Infections
Venae CavaeKetamine
MeningoencephalitisLaboratory Infection
EicosanoidsStreptococcus suis
Protein Kinase CRabbits
Ciliary BodyTantalum
Heart Valve Prosthesis ImplantationGuinea Pigs
Monkey DiseasesEpidermis
Pneumonia, ViralUrinary Calculi
Radiographic Image Interpretation, Computer-AssistedIntrauterine Devices
GranulomaAspergillosis
Cardioplegic SolutionsThrombosis
PropofolCalculi
Genitalia, MaleMucins
Pancreatic NeoplasmsSkin Neoplasms
Membrane GlycoproteinsPneumovirus Infections
Hypoglycemic AgentsOptic Nerve Diseases
EtomidateMite Infestations
Mice, NudeSterilization, Tubal
Bone and BonesPyrazines
Rodent DiseasesHeart Valve Prosthesis
PneumovirusCystitis
CineradiographyChoristoma
DustHeart-Assist Devices
StentsBronchoalveolar Lavage Fluid
MegacolonCottontail rabbit papillomavirus
Retrobulbar HemorrhageOligonucleotides, Antisense
Uterine NeoplasmsPleurisy
Mice, ObeseCarcinoma, Acinar Cell
Animals, LaboratoryIvermectin
PeptidesBordetella bronchiseptica
Carcinoma, Squamous CellTumor Virus Infections
Orbital DiseasesStreptococcal Infections
GuanidinesCervix Uteri
InsecticidesDiabetes Mellitus, Experimental
LeiomyomaPinacidil
Vitamin EInfarction
PneumoconiosisMacaca fascicularis
Diabetic NephropathiesPneumonia, Bacterial
IsoenzymesParalysis
MucormycosisBacterial Infections
Catheterization, Central VenousKeratoacanthoma
Common Bile DuctProteolipids
Endocarditis, BacterialMeningitis, Bacterial
MelanomaTrematode Infections
AgingSpinal Cord
Eye HemorrhageMinerals
Gene ExpressionVision Disorders
Macrophages, AlveolarPotassium Channels
Mitral ValveAntigens, Neoplasm
Antigens, Polyomavirus TransformingHeart Diseases
Animals, NewbornEnkephalin, Methionine
Pregnancy, AnimalPrenatal Exposure Delayed Effects
WeaningBiogenic Polyamines
Breast NeoplasmsLung Neoplasms
Mammary Neoplasms, ExperimentalOrnithine Decarboxylase
Adenosylmethionine DecarboxylaseEflornithine
Enzyme InhibitorsNeoplasm Recurrence, Local
Neoplasm MetastasisPolyamines
Alkaline PhosphataseY Chromosome
Mouth DiseasesBiocompatible Materials
Materials TestingPapillomavirus Infections
Corneal NeovascularizationGranulation Tissue
NaltrexoneNarcotic Antagonists
Publication author name
  Griffith JW
Griffith J
Select publications
  Tevethia MJ. Bonneau RH. Griffith JW. Mylin L. A simian virus 40 large T-antigen segment containing amino acids 1 to 127 and expressed under the control of the rat elastase-1 promoter produces pancreatic acinar carcinomas in transgenic mice. 1997 Nov. J Virol. 71(11):8157-66.
National Cancer Institute
Wilson RP. Griffith JW. Mycotic thromboses in sheep implanted with biomedical cardiac devices. 1997 Oct. Lab Anim Sci. 47(5):554-6.
Peng X. Griffith JW. Han R. Lang CM. Kreider JW. Development of keratoacanthomas and squamous cell carcinomas in transgenic rabbits with targeted expression of EJras oncogene in epidermis. 1999 Jul. Am J Pathol. 155(1):315-24.
Peng X. Griffith JW. Lang CM. Reinitiated expression of EJras transgene in targeted epidermal cells of transgenic rabbits by cottontail rabbit papillomavirus infection. 2001 Oct 10. Cancer Lett. 171(2):193-200.
Manni A. Washington S. Griffith JW. Verderame MF. Mauger D. Demers LM. Samant RS. Welch DR. Influence of polyamines on in vitro and in vivo features of aggressive and metastatic behavior by human breast cancer cells. 2002. Clin Exp Metastasis. 19(2):95-105.
National Cancer Institute
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