John Ellis All publications ( 10 ) Huang XP. Ellis J. Mutational disruption of a conserved disulfide bond in muscarinic acetylcholine receptors attenuates positive homotropic cooperativity between multiple allosteric sites and has subtype-dependent effects on the affinities of muscarinic allosteric ligands. 2007 Mar. Mol Pharmacol. 71(3):759-68. Prilla S. Schrobang J. Ellis J. Höltje HD. Mohr K. Allosteric interactions with muscarinic acetylcholine receptors: complex role of the conserved tryptophan M2422Trp in a critical cluster of amino acids for baseline affinity, subtype selectivity, and cooperativity. 2006 Jul. Mol Pharmacol. 70(1):181-93. National Institute on Aging Huang XP. Prilla S. Mohr K. Ellis J. Critical amino acid residues of the common allosteric site on the M2 muscarinic acetylcholine receptor: more similarities than differences between the structurally divergent agents gallamine and bis(ammonio)alkane-type hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium]dibromide. 2005 Sep. Mol Pharmacol. 68(3):769-78. National Institute on Aging Tränkle C. Dittmann A. Schulz U. Weyand O. Buller S. Jöhren K. Heller E. Birdsall NJ. Holzgrabe U. Ellis J. Höltje HD. Mohr K. Atypical muscarinic allosteric modulation: cooperativity between modulators and their atypical binding topology in muscarinic M2 and M2/M5 chimeric receptors. 2005 Dec. Mol Pharmacol. 68(6):1597-610. National Institute on Aging Ford DJ. Essex A. Spalding TA. Burstein ES. Ellis J. Homologous mutations near the junction of the sixth transmembrane domain and the third extracellular loop lead to constitutive activity and enhanced agonist affinity at all muscarinic receptor subtypes. 2002 Mar. J Pharmacol Exp Ther. 300(3):810-7. National Institute on Aging Buller S. Zlotos DP. Mohr K. Ellis J. Allosteric site on muscarinic acetylcholine receptors: a single amino acid in transmembrane region 7 is critical to the subtype selectivities of caracurine V derivatives and alkane-bisammonium ligands. 2002 Jan. Mol Pharmacol. 61(1):160-8. National Institute on Aging Ellis J. Seidenberg M. Interactions of alcuronium, TMB-8, and other allosteric ligands with muscarinic acetylcholine receptors: studies with chimeric receptors. 2000 Dec. Mol Pharmacol. 58(6):1451-60. National Institute on Aging Ellis J. Seidenberg M. Site-directed mutagenesis implicates a threonine residue in TM6 in the subtype selectivities of UH-AH 37 and pirenzepine at muscarinic receptors. 2000 Aug. Pharmacology. 61(2):62-9. National Institute on Aging Ellis J. Seidenberg M. Competitive and allosteric interactions of 6-chloro-5,10-dihydro-5-[(1-methyl-4-piperidinyl)acetyl]-11H-di benzo[b,e][1, 4]diazepine-11-one hydrochloride (UH-AH 37) at muscarinic receptors, via distinct epitopes. 1999 Jan 15. Biochem Pharmacol. 57(2):181-6. National Institute on Aging Gnagey AL. Seidenberg M. Ellis J. Site-directed mutagenesis reveals two epitopes involved in the subtype selectivity of the allosteric interactions of gallamine at muscarinic acetylcholine receptors. 1999 Dec. Mol Pharmacol. 56(6):1245-53. National Institute on Aging