Kristin A. Eckert All publications ( 20 ) Hile SE. Eckert KA. DNA polymerase kappa produces interrupted mutations and displays polar pausing within mononucleotide microsatellite sequences. 2008 Feb. Nucleic Acids Res. 36(2):688-96. Jacob KD. Eckert KA. Escherichia coli DNA polymerase IV contributes to spontaneous mutagenesis at coding sequences but not microsatellite alleles. 2007 Jun 1. Mutat Res. 619(1-2):93-103. National Cancer Institute Gestl EE. Eckert KA. Loss of DNA minor groove interactions by exonuclease-deficient Klenow polymerase inhibits O6-methylguanine and abasic site translesion synthesis. 2005 May 10. Biochemistry. 44(18):7059-68. Dalal S. Hile S. Eckert KA. Sun KW. Starcevic D. Sweasy JB. Prostate-Cancer-Associated I260M Variant of DNA Polymerase beta Is a Sequence-Specific Mutator. 2005 Dec 6. Biochemistry. 44(48):15664-15673. Hamid S. Eckert KA. Effect of DNA polymerase beta loop variants on discrimination of O6-methyldeoxyguanosine modification present in the nucleotide versus template substrate. 2005 Aug 2. Biochemistry. 44(30):10378-87. Meehan WJ. Samant RS. Hopper JE. Carrozza MJ. Shevde LA. Workman JL. Eckert KA. Verderame MF. Welch DR. Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription. 2004 Jan 9. J Biol Chem. 279(2):1562-9. National Cancer Institute Hile SE. Eckert KA. Positive correlation between DNA polymerase alpha-primase pausing and mutagenesis within polypyrimidine/polypurine microsatellite sequences. 2004 Jan 16. J Mol Biol. 335(3):745-59. National Cancer Institute Maneval ML. Eckert KA. Effects of oxidative and alkylating damage on microsatellite instability in nontumorigenic human cells. 2004 Feb 26. Mutat Res. 546(1-2):29-38. National Cancer Institute Eckert KA. Yan G. Hile SE. Mutation rate and specificity analysis of tetranucleotide microsatellite DNA alleles in somatic human cells. 2002 Jul. Mol Carcinog. 34(3):140-50. National Cancer Institute Khare V. Eckert KA. The proofreading 3'-->5' exonuclease activity of DNA polymerases: a kinetic barrier to translesion DNA synthesis. 2002 Dec 29. Mutat Res. 510(1-2):45-54. Eckert KA. Mowery A. Hile SE. Misalignment-mediated DNA polymerase beta mutations: comparison of microsatellite and frame-shift error rates using a forward mutation assay. 2002 Aug 20. Biochemistry. 41(33):10490-8. National Cancer Institute Khare V. Eckert KA. The 3' --> 5' exonuclease of T4 DNA polymerase removes premutagenic alkyl mispairs and contributes to futile cycling at O6-methylguanine lesions. 2001 Jun 29. J Biol Chem. 276(26):24286-92. Opresko PL. Shiman R. Eckert KA. Hydrophobic interactions in the hinge domain of DNA polymerase beta are important but not sufficient for maintaining fidelity of DNA synthesis. 2000 Sep 19. Biochemistry. 39(37):11399-407. Hile SE. Yan G. Eckert KA. Somatic mutation rates and specificities at TC/AG and GT/CA microsatellite sequences in nontumorigenic human lymphoblastoid cells. 2000 Mar 15. Cancer Res. 60(6):1698-703. National Cancer Institute Eckert KA. Yan G. Mutational analyses of dinucleotide and tetranucleotide microsatellites in Escherichia coli: influence of sequence on expansion mutagenesis. 2000 Jul 15. Nucleic Acids Res. 28(14):2831-8. National Cancer Institute Eckert KA. Opresko PL. DNA polymerase mutagenic bypass and proofreading of endogenous DNA lesions. 1999 Mar 8. Mutat Res. 424(1-2):221-36. Opresko PL. Sweasy JB. Eckert KA. The mutator form of polymerase beta with amino acid substitution at tyrosine 265 in the hinge region displays an increase in both base substitution and frame shift errors. 1998 Feb 24. Biochemistry. 37(8):2111-9. Eckert KA. Hile SE. Alkylation-induced frameshift mutagenesis during in vitro DNA synthesis by DNA polymerases alpha and beta. 1998 Dec 3. Mutat Res. 422(2):255-69. Eckert KA. Hile SE. Vargo PL. Development and use of an in vitro HSV-tk forward mutation assay to study eukaryotic DNA polymerase processing of DNA alkyl lesions. 1997 Apr 1. Nucleic Acids Res. 25(7):1450-7. Hite JM. Eckert KA. Cheng KC. Factors affecting fidelity of DNA synthesis during PCR amplification of d(C-A)n.d(G-T)n microsatellite repeats. 1996 Jun 15. Nucleic Acids Res. 24(12):2429-34.