1.) Understanding the mechanism of action of environmental carcinogens (aromatic amines, heterocyclic aromatic amines, nitrosamines, polycyclic aromatic hydrocarbons and their nitrated derivatives); these studies include synthesis, metabolism, macromolecular binding and bioassay of potential carcinogens


2.) Identifying environmental carcinogens that may be involved in human breast and prostate cancers


3.) Developing and validating biomarkers for molecular epidemiologic and clinical chemoprevention intervention studies providing insights into mechanisms pertaining to the etiology of tobacco-related cancers, i.e. identification of biochemical, cellular, and molecular events that contribute to such cancers


4.) Developing novel chemopreventive agents (organoselenium compounds) against chemically-induced tumors in laboratory animals (lung, oral, breast, colon, prostate); synthesis including radiolabelled compounds and examine the possible mechanism(s) responsible for chemoprevention


5.) Devising mechanism-based strategies for the control of tobacco-induced and environmentally-related cancers by innovative approaches


6.) Examining the influence of selenium on biomarkers of prostate cancer risk: clinical pilot studies