Natalia A. Loktionova
Photo
Academic title Instructor
College College of Medicine
Campuses Penn State Milton S. Hershey Medical Center
Department Cellular and Molecular Physiology
Graduate programs
Email Phone
  nxl3@psu.edu
  717 531 6987
 
Educational background
  Ph.D. in Biology, Institute of Toxicology, St. Petersburg, Russia, 1987
Areas of expertise
 
Antineoplastic AgentsCarmustine
GuanineMethyltransferases
Antineoplastic Agents, AlkylatingO(6)-Methylguanine-DNA Methyltransferase
Conserved SequenceLysine
Enzyme InhibitorsOligodeoxyribonucleotides
DNA AdductsEthylene Dibromide
MutagensCell Nucleus
Hematopoietic Stem CellsLuminescent Proteins
Recombinant Fusion ProteinsHydrocarbons, Halogenated
PteridinesDeoxyguanosine
Folic Acid
Publication author name
  Loktionova NA
Select publications
  Loktionova NA. Pegg AE. Point mutations in human O6-alkylguanine-DNA alkyltransferase prevent the sensitization by O6-benzylguanine to killing by N,N'-bis (2-chloroethyl)-N-nitrosourea. 1996 Apr 1. Cancer Res. 56(7):1578-83.
National Cancer Institute
Loktionova NA. Xu-Welliver M. Crone TM. Kanugula S. Pegg AE. Protection of CHO cells by mutant forms of O6-alkylguanine-DNA alkyltransferase from killing by 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine or O6-benzyl-8-oxoguanine. 1999 Jul 15. Biochem Pharmacol. 58(2):237-44.
National Cancer Institute
Xu-Welliver M. Kanugula S. Loktionova NA. Crone TM. Pegg AE. Conserved residue lysine165 is essential for the ability of O6-alkylguanine-DNA alkyltransferase to react with O6-benzylguanine. 2000 Apr 15. Biochem J. 347(Pt 2):527-34.
National Cancer Institute
Pegg AE. Goodtzova K. Loktionova NA. Kanugula S. Pauly GT. Moschel RC. Inactivation of human O(6)-alkylguanine-DNA alkyltransferase by modified oligodeoxyribonucleotides containing O(6)-benzylguanine. 2001 Mar. J Pharmacol Exp Ther. 296(3):958-65.
National Cancer Institute
Loktionova NA. Pegg AE. Interaction of mammalian O(6)-alkylguanine-DNA alkyltransferases with O(6)-benzylguanine. 2002 Apr 15. Biochem Pharmacol. 63(8):1431-42.
National Cancer Institute
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