Philip Lazarus All publications ( 68 ) Nichenametla SN. Ellison I. Calcagnotto A. Lazarus P. Muscat JE. Richie JP. Functional significance of the GAG trinucleotide-repeat polymorphism in the gene for the catalytic subunit of gamma-glutamylcysteine ligase. 2008 Sep 1. Free Radic Biol Med. 45(5):645-50. Chen G. Dellinger RW. Sun D. Spratt TE. Lazarus P. Glucuronidation of tobacco-specific nitrosamines by UGT2B10. 2008 May. Drug Metab Dispos. 36(5):824-30. Lazarus P. Gender issues and the molecular epidemiology of lung cancer risk. 2008 May. Clin Lung Cancer. 9(3):140. Chen G. Dellinger RW. Gallagher CJ. Sun D. Lazarus P. Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines. 2008 Mar. Pharmacogenet Genomics. 18(3):181-91. Varela-Lema L. Taioli E. Ruano-Ravina A. Barros-Dios JM. Anantharaman D. Benhamou S. Boccia S. Bhisey RA. Cadoni G. Capoluongo E. Chen CJ. Foulkes W. Goloni-Bertollo EM. Hatagima A. Hayes RB. Katoh T. Koifman S. Lazarus P. Manni JJ. Mahimkar M. Morita S. Park J. Park KK. Pavarino Bertelli EC. de Souza Fonseca Ribeiro EM. Roy B. Spitz MR. Strange RC. Wei Q. Ragin CC. Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers: a HuGE-GSEC review. 2008 Jun. Genet Med. 10(6):369-84. Muscat JE. Pittman B. Kleinman W. Lazarus P. Stellman SD. Richie JP. Comparison of CYP1A2 and NAT2 phenotypes between black and white smokers. 2008 Jul 25. Biochem Pharmacol. . Chen G. Blevins-Primeau AS. Dellinger RW. Muscat JE. Lazarus P. Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism. 2007 Oct 1. Cancer Res. 67(19):9024-9. Zheng Y. Sun D. Sharma AK. Chen G. Amin S. Lazarus P. Elimination of antiestrogenic effects of active tamoxifen metabolites by glucuronidation. 2007 Oct. Drug Metab Dispos. 35(10):1942-8. Sun D. Sharma AK. Dellinger RW. Blevins-Primeau AS. Balliet RM. Chen G. Boyiri T. Amin S. Lazarus P. Glucuronidation of active tamoxifen metabolites by the human UDP glucuronosyltransferases. 2007 Nov. Drug Metab Dispos. 35(11):2006-14. Dellinger RW. Chen G. Blevins-Primeau AS. Krzeminski J. Amin S. Lazarus P. Glucuronidation of PhIP and N-OH-PhIP by UDP-glucuronosyltransferase 1A10. 2007 Nov. Carcinogenesis. 28(11):2412-8. Gallagher CJ. Muscat JE. Hicks AN. Zheng Y. Dyer AM. Chase GA. Richie J. Lazarus P. The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer. 2007 Apr. Cancer Epidemiol Biomarkers Prev. 16(4):823-8. National Cancer Institute National Institute for Dental and Craniofacial Research Gallagher CJ. Kadlubar FF. Muscat JE. Ambrosone CB. Lang NP. Lazarus P. The UGT2B17 gene deletion polymorphism and risk of prostate cancer. A case-control study in Caucasians. 2007. Cancer Detect Prev. 31(4):310-5. Dellinger RW. Fang JL. Chen G. Weinberg R. Lazarus P. Importance of UDP-glucuronosyltransferase 1A10 (UGT1A10) in the detoxification of polycyclic aromatic hydrocarbons: decreased glucuronidative activity of the UGT1A10139Lys isoform. 2006 Jun. Drug Metab Dispos. 34(6):943-9. National Cancer Institute National Institute for Dental and Craniofacial Research Sun D. Chen G. Dellinger RW. Duncan K. Fang JL. Lazarus P. Characterization of tamoxifen and 4-hydroxytamoxifen glucuronidation by human UGT1A4 variants. 2006. Breast Cancer Res. 8(4):R50. National Cancer Institute National Institute for Dental and Craniofacial Research Lazarus P. Zheng Y. Aaron Runkle E. Muscat JE. Wiener D. Genotype-phenotype correlation between the polymorphic UGT2B17 gene deletion and NNAL glucuronidation activities in human liver microsomes. 2005 Nov. Pharmacogenet Genomics. 15(11):769-78. National Cancer Institute National Institute for Dental and Craniofacial Research Park JY. Chen L. Elahi A. Lazarus P. Tockman MS. Genetic analysis of microsomal epoxide hydrolase gene and its association with lung cancer risk. 2005 Jun. Eur J Cancer Prev. 14(3):223-30. National Cancer Institute National Institute for Dental and Craniofacial Research Almahmeed T. Boyle JO. Cohen EG. Carew JF. Du B. Altorki NK. Kopelovich L. Fang JL. Lazarus P. Subbaramaiah K. Dannenberg AJ. Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract. 2004 May. Carcinogenesis. 25(5):793-9. National Cancer Institute National Institute for Dental and Craniofacial Research Raimondi S. Benhamou S. Coutelle C. Garte S. Hayes R. Kiemeney L. Lazarus P. Marchand LL. Morita S. Povey A. Romkes M. Zijno A. Taioli E. Association of metabolic gene polymorphisms with alcohol consumption in controls. 2004 Mar-Apr. Biomarkers. 9(2):180-9. Smits KM. Benhamou S. Garte S. Weijenberg MP. Alamanos Y. Ambrosone C. Autrup H. Autrup JL. Baranova H. Bathum L. Boffetta P. Bouchardy C. Brockmoller J. Butkiewicz D. Cascorbi I. Clapper ML. Coutelle C. Daly AK. Muzi G. Dolzan V. Duzhak TG. Farker K. Golka K. Haugen A. Hein DW. Hildesheim A. Hirvonen A. Hsieh LL. Ingelman-Sundberg M. Kalina I. Kang D. Katoh T. Kihara M. Ono-Kihara M. Kim H. Kiyohara C. Kremers P. Lazarus P. Le Marchand L. Lechner MC. London S. Manni JJ. Maugard CM. Morgan GJ. Morita S. Nazar-Stewart V. Kristensen VN. Oda Y. Parl FF. Peters WH. Rannug A. Rebbeck T. Pinto LF. Risch A. Romkes M. Salagovic J. Schoket B. Seidegard J. Shields PG. Sim E. Sinnett D. Strange RC. Stucker I. Sugimura H. To-Figueras J. Vineis P. Yu MC. Zheng W. Pedotti P. Taioli E. Association of metabolic gene polymorphisms with tobacco consumption in healthy controls. 2004 Jun 10. Int J Cancer. 110(2):266-70. Park J. Chen L. Shade K. Lazarus P. Seigne J. Patterson S. Helal M. Pow-Sang J. Asp85tyr polymorphism in the udp-glucuronosyltransferase (UGT) 2B15 gene and the risk of prostate cancer. 2004 Jun. J Urol. 171(6 Pt 1):2484-8. Wiener D. Doerge DR. Fang JL. Upadhyaya P. Lazarus P. Characterization of N-glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human liver: importance of UDP-glucuronosyltransferase 1A4. 2004 Jan. Drug Metab Dispos. 32(1):72-9. National Cancer Institute National Institute for Dental and Craniofacial Research Fang JL. Lazarus P. Correlation between the UDP-glucuronosyltransferase (UGT1A1) TATAA box polymorphism and carcinogen detoxification phenotype: significantly decreased glucuronidating activity against benzo(a)pyrene-7,8-dihydrodiol(-) in liver microsomes from subjects with the UGT1A1*28 variant. 2004 Jan. Cancer Epidemiol Biomarkers Prev. 13(1):102-9. National Cancer Institute National Institute for Dental and Craniofacial Research Muscat JE. Kleinman W. Colosimo S. Muir A. Lazarus P. Park J. Richie JP. Enhanced protein glutathiolation and oxidative stress in cigarette smokers. 2004 Feb 15. Free Radic Biol Med. 36(4):464-70. National Cancer Institute Wiener D. Fang JL. Dossett N. Lazarus P. Correlation between UDP-glucuronosyltransferase genotypes and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone glucuronidation phenotype in human liver microsomes. 2004 Feb 1. Cancer Res. 64(3):1190-6. Public Health Service National Institute for Dental and Craniofacial Research Park J. Chen L. Tockman MS. Elahi A. Lazarus P. The human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) DNA repair enzyme and its association with lung cancer risk. 2004 Feb. Pharmacogenetics. 14(2):103-9. National Cancer Institute Park JY. Schantz SP. Lazarus P. Epoxide hydrolase genotype and orolaryngeal cancer risk: interaction with GSTM1 genotype. 2003 Jul. Oral Oncol. 39(5):483-90. National Cancer Institute National Institute for Dental and Craniofacial Research Chen L. Elahi A. Pow-Sang J. Lazarus P. Park J. Association between polymorphism of human oxoguanine glycosylase 1 and risk of prostate cancer. 2003 Dec. J Urol. 170(6 Pt 1):2471-4. Hashibe M. Brennan P. Strange RC. Bhisey R. Cascorbi I. Lazarus P. Oude Ophuis MB. Benhamou S. Foulkes WD. Katoh T. Coutelle C. Romkes M. Gaspari L. Taioli E. Boffetta P. Meta- and pooled analyses of GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes and risk of head and neck cancer. 2003 Dec. Cancer Epidemiol Biomarkers Prev. 12(12):1509-17. Elahi A. Bendaly J. Zheng Z. Muscat JE. Richie JP. Schantz SP. Lazarus P. Detection of UGT1A10 polymorphisms and their association with orolaryngeal carcinoma risk. 2003 Aug 15. Cancer. 98(4):872-80. National Cancer Institute National Institute for Dental and Craniofacial Research Stellman SD. Chen Y. Muscat JE. Djordjevic MV. Richie JP. Lazarus P. Thompson S. Altorki N. Berwick M. Citron ML. Harlap S. Kaur TB. Neugut AI. Olson S. Travaline JM. Witorsch P. Zhang ZF. Lung cancer risk in white and black Americans. 2003 Apr. Ann Epidemiol. 13(4):294-302. National Cancer Institute Strudwick S. Carastro LM. Stagg T. Lazarus P. Differential transcription-coupled translational inhibition of human p53 expression: a potentially important mechanism of regulating p53 expression in normal versus tumor tissue. 2003 Apr. Mol Cancer Res. 1(6):463-74. National Cancer Institute Huang Q. Yu GP. McCormick SA. Mo J. Datta B. Mahimkar M. Lazarus P. Schäffer AA. Desper R. Schantz SP. Genetic differences detected by comparative genomic hybridization in head and neck squamous cell carcinomas from different tumor sites: construction of oncogenetic trees for tumor progression. 2002 Jun. Genes Chromosomes Cancer. 34(2):224-33. Elahi A. Zheng Z. Park J. Eyring K. McCaffrey T. Lazarus P. The human OGG1 DNA repair enzyme and its association with orolaryngeal cancer risk. 2002 Jul. Carcinogenesis. 23(7):1229-34. National Institute for Dental and Craniofacial Research Fang JL. Beland FA. Doerge DR. Wiener D. Guillemette C. Marques MM. Lazarus P. Characterization of benzo(a)pyrene-trans-7,8-dihydrodiol glucuronidation by human tissue microsomes and overexpressed UDP-glucuronosyltransferase enzymes. 2002 Apr 1. Cancer Res. 62(7):1978-86. Public Health Service National Institute for Dental and Craniofacial Research Zheng Z. Fang JL. Lazarus P. Glucuronidation: an important mechanism for detoxification of benzo[a]pyrene metabolites in aerodigestive tract tissues. 2002 Apr. Drug Metab Dispos. 30(4):397-403. National Cancer Institute National Institute for Dental and Craniofacial Research Zheng Z. Park JY. Guillemette C. Schantz SP. Lazarus P. Tobacco carcinogen-detoxifying enzyme UGT1A7 and its association with orolaryngeal cancer risk. 2001 Sep 19. J Natl Cancer Inst. 93(18):1411-8. National Cancer Institute National Institute for Dental and Craniofacial Research Liu S. Park JY. Schantz SP. Stern JC. Lazarus P. Elucidation of CYP2E1 5' regulatory RsaI/Pstl allelic variants and their role in risk for oral cancer. 2001 Jul. Oral Oncol. 37(5):437-45. National Cancer Institute National Institute for Dental and Craniofacial Research Garte S. Gaspari L. Alexandrie AK. Ambrosone C. Autrup H. Autrup JL. Baranova H. Bathum L. Benhamou S. Boffetta P. Bouchardy C. Breskvar K. Brockmoller J. Cascorbi I. Clapper ML. Coutelle C. Daly A. Dell'Omo M. Dolzan V. Dresler CM. Fryer A. Haugen A. Hein DW. Hildesheim A. Hirvonen A. Hsieh LL. Ingelman-Sundberg M. Kalina I. Kang D. Kihara M. Kiyohara C. Kremers P. Lazarus P. Le Marchand L. Lechner MC. van Lieshout EM. London S. Manni JJ. Maugard CM. Morita S. Nazar-Stewart V. Noda K. Oda Y. Parl FF. Pastorelli R. Persson I. Peters WH. Rannug A. Rebbeck T. Risch A. Roelandt L. Romkes M. Ryberg D. Salagovic J. Schoket B. Seidegard J. Shields PG. Sim E. Sinnet D. Strange RC. Stücker I. Sugimura H. To-Figueras J. Vineis P. Yu MC. Taioli E. Metabolic gene polymorphism frequencies in control populations. 2001 Dec. Cancer Epidemiol Biomarkers Prev. 10(12):1239-48. Lazarus P. Park JY. Metabolizing enzyme genotype and risk for upper aerodigestive tract cancer. 2000 Sep. Oral Oncol. 36(5):421-31. Ren Q. Murphy SE. Zheng Z. Lazarus P. O-Glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1- (3-pyridyl)-1-butanol (NNAL) by human UDP-glucuronosyltransferases 2B7 and 1A9. 2000 Nov. Drug Metab Dispos. 28(11):1352-60. National Cancer Institute National Institute for Dental and Craniofacial Research Kaur TB. Travaline JM. Gaughan JP. Richie JP. Stellman SD. Lazarus P. Role of polymorphisms in codons 143 and 160 of the O6-alkylguanine DNA alkyltransferase gene in lung cancer risk. 2000 Mar. Cancer Epidemiol Biomarkers Prev. 9(3):339-42. National Cancer Institute National Institute for Dental and Craniofacial Research Park LY. Muscat JE. Kaur T. Schantz SP. Stern JC. Richie JP. Lazarus P. Comparison of GSTM polymorphisms and risk for oral cancer between African-Americans and Caucasians. 2000 Mar. Pharmacogenetics. 10(2):123-31. National Cancer Institute National Institute for Dental and Craniofacial Research Ren Q. Murphy SE. Dannenberg AJ. Park JY. Tephly TR. Lazarus P. Glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by rat UDP-glucuronosyltransferase 2B1. 1999 Sep. Drug Metab Dispos. 27(9):1010-6. National Cancer Institute National Institute for Dental and Craniofacial Research Qin GZ. Park JY. Chen SY. Lazarus P. A high prevalence of p53 mutations in pre-malignant oral erythroplakia. 1999 Jan 29. Int J Cancer. 80(3):345-8. National Cancer Institute National Institute for Dental and Craniofacial Research Park JY. Schantz SP. Stern JC. Kaur T. Lazarus P. Association between glutathione S-transferase pi genetic polymorphisms and oral cancer risk. 1999 Aug. Pharmacogenetics. 9(4):497-504. National Cancer Institute National Institute for Dental and Craniofacial Research Lazarus P. Sheikh SN. Ren Q. Schantz SP. Stern JC. Richie JP. Park JY. p53, but not p16 mutations in oral squamous cell carcinomas are associated with specific CYP1A1 and GSTM1 polymorphic genotypes and patient tobacco use. 1998 Mar. Carcinogenesis. 19(3):509-14. National Cancer Institute National Institute for Dental and Craniofacial Research Sheikh SN. Lazarus P. Re-usable DNA template for the polymerase chain reaction. 1997 Sep 1. Nucleic Acids Res. 25(17):3537-42. National Cancer Institute National Institute for Dental and Craniofacial Research Park JY. Muscat JE. Ren Q. Schantz SP. Harwick RD. Stern JC. Pike V. Richie JP. Lazarus P. CYP1A1 and GSTM1 polymorphisms and oral cancer risk. 1997 Oct. Cancer Epidemiol Biomarkers Prev. 6(10):791-7. National Cancer Institute Muscat JE. Lazarus P. Risk of lung cancer from environmental exposures to tobacco smoke. 1997 Nov. Cancer Causes Control. 8(6):929. Caruana SM. Zwiebel N. Cocker R. McCormick SA. Eberle RC. Lazarus P. p53 alteration and human papilloma virus infection in paranasal sinus cancer. 1997 Apr 1. Cancer. 79(7):1320-8. National Cancer Institute Lazarus P. Caruana S. Typing of common human papilloma virus strains by multiplex PCR. 1996 Dec 1. Anal Biochem. 243(1):198-201. National Cancer Institute National Institute for Dental and Craniofacial Research Lazarus P. Stern J. Zwiebel N. Fair A. Richie JP. Schantz S. Relationship between p53 mutation incidence in oral cavity squamous cell carcinomas and patient tobacco use. 1996 Apr. Carcinogenesis. 17(4):733-9. National Cancer Institute National Institute for Dental and Craniofacial Research Lazarus P. Idris AM. Kim J. Calcagnotto A. Hoffmann D. p53 mutations in head and neck squamous cell carcinomas from Sudanese snuff (toombak) users. 1996. Cancer Detect Prev. 20(4):270-8. National Institute of General Medical Sciences National Institute for Dental and Craniofacial Research Lazarus P. Garewal HS. Sciubba J. Zwiebel N. Calcagnotto A. Fair A. Schaefer S. Richie JP. A low incidence of p53 mutations in pre-malignant lesions of the oral cavity from non-tobacco users. 1995 Feb 8. Int J Cancer. 60(4):458-63. National Institute for Dental and Craniofacial Research Lazarus P. Calcagnotto A. Identification and partial characterization of the c-jun oncogene in Xenopus laevis. 1994 Nov 11. Cancer Lett. 86(2):201-8. National Institute for Dental and Craniofacial Research Vancutsem PM. Lazarus P. Williams GM. Frequent and specific mutations of the rat p53 gene in hepatocarcinomas induced by tamoxifen. 1994 Jul 15. Cancer Res. 54(14):3864-7. Lazarus P. Calcagnotto A. Williams GM. Alvi N. Sequence of the rat hypoxanthine guanine phosphoribosyl transferase (HPRT) transcriptional promoter region in wild-type and mutant rat liver epithelial cell lines. 1994 Dec. Mutat Res. 325(4):117-23. National Institute of Environmental Health Sciences Lazarus P. The regulation of translation by the 5' untranslated region of Xenopus c-myc I mRNA during early development. 1992 May. Oncogene. 7(5):1037-41. Ronai Z. Robinson R. Rutberg S. Lazarus P. Sardana M. Aldolase-DNA interactions in a SEWA cell system. 1992 Feb 28. Biochim Biophys Acta. 1130(1):20-8. National Cancer Institute Lazarus P. Parkin N. Sonenberg N. Developmental regulation of translation by the 5' noncoding region of murine c-myc mRNA in Xenopus laevis. 1988 Nov. Oncogene. 3(5):517-21. Lazarus P. Panasci LC. Mechanism of decrease of protein synthesis by sodium cyanate in murine P388 leukemia cells. 1987 Oct 1. Cancer Res. 47(19):5102-7. Lazarus P. Panasci LC. Further studies on amino acid transport in murine P388 leukemia cells in vitro. Presence of system y+. 1987 Apr 9. Biochim Biophys Acta. 898(2):154-8. National Institute of Neurological Disorders and Stroke Lazarus P. Panasci LC. Characterization of L-threonine and L-glutamine transport in murine P388 leukemia cells in vitro. Presence of an N-like amino acid transport system. 1986 Apr 25. Biochim Biophys Acta. 856(3):488-95. National Institute of Neurological Disorders and Stroke Lazarus P. Dufour M. Isabel G. Panasci LC. In vitro comparative studies of the myelotoxicity and antitumor activity of 6-[bis-(2-chloroethyl)-amino]-6-deoxy-D-glucose versus melphalan utilizing the CFU-C and HTSCA assays. 1986. Cancer Chemother Pharmacol. 16(2):148-52. National Cancer Institute Panasci LC. Dufour M. Chevalier L. Isabel G. Lazarus P. McQuillan A. Arbit E. Brem S. Feindel W. Utilization of the HTSCA and CFU-C assay to identify two new 2-chloroethylnitrosourea congeners of amino acid amides with increased in vitro activity against human glioma compared with BCNU. 1985. Cancer Chemother Pharmacol. 14(2):156-9. National Cancer Institute Dufour M. St Germain J. Skalski V. Dorato A. Lazarus P. Panasci LC. Effect of administration of sodium cyanate and melphalan on the lifespan of P388 tumor-bearing CD2F1 mice. 1984. Cancer Chemother Pharmacol. 12(2):94-7. National Cancer Institute Lazarus P. Germina JS. Dufour M. Palmer G. Wallace D. Panasci LC. Comparison of the transport of chlorozotocin and CCNU in L1210 leukemia and murine bone marrow cells in vitro. 1983. Cancer Chemother Pharmacol. 11(3):159-61. National Cancer Institute Panasci LC. Skalski V. St-Germain J. Lazarus P. Shinder M. Margolese R. Pharmacology and toxicity of Ip streptozocin in ovarian cancer: a case report. 1982 Jul. Cancer Treat Rep. 66(7):1595-6. National Cancer Institute