 |  | |
 |
|
| Educational background |
| |
B.S., Duke University
Ph.D., University of South Florida College of Medicine
|
|
| Research interests |
| |
- Investigation into the etiology of large granular lymphocyte (LGL) leukemia. We are looking for a transmissable viral component to LGL leukemia. There is data to support this theory, and we expect to isolate and characterize the virus that causes LGL leukemia. In addition, we are using microarray technology to create a fingerprint of LGL leukemia, and to relate it to rheumatoid arthritis. This will allow us to identify those genes that are responsible for the LGL leukemia phenotype, to determine a relationship between LGL leukemia and rheumatoid arthritis, and to test the response of both diseases to drug treatments.
- Identification of the molecular basis for metastatic disease in colorectal cancer. For the past eight years I have been working on the Src oncogene and its role in colorectal cancer progression with an emphasis on metastasis. We have identified upstream activators and downstream targets of Src. The relationship of Src to other oncogenes and tumor suppressor genes, including osteopontin, Ras, p21, p53, and adenomatous polyposis coli (APC) have been studied. We have examined a number of phenotypic effects of Src, and are in the process of using novel Src specific inhibitors to determine the degree of metastatic inhibition they will exert in vivo. Current studies are being conducted to examine the effects of Src on tumor suppressor genes in both colon and breast cancer. The goal of these studies is to identify an effective target for chemotherapy.
|
|
| Areas of expertise |
|
| Publication author name |
|
|
|
|
|
