Targeted Transgenesis and Transgene Expression: Stem Cell Differentiation/Osteogenesis

Dr. Bronson is Director of the Transgenic Core within the Section of Research Resources, is Director of the Animal Core and project team member for the Penn State University Juvenile Diabetes Research Foundation Diabetic Retinopathy Center, is Director of the Summer Undergraduate Research Internship Program, and Co-director of the Intercollege Graduate Degree Program in Genetics of the Huck Institute for Life Sciences. Dr. Bronson has 15 years of experience in generating and studying genetically altered mice as models for understanding and treating human disease. She is known for the creation of targeted transgenic lines, where small recombinant transgenic sequences as well as bacterial artificial chromosome-based transgenics are introduced in a single-copy at the X-linked Hprt locus by a directly selectable homologous recombination event in murine embryonic stem cells. Dr. Bronson's research interests include stem cell differentiation, in particular, embryonic stem cell differentiation into bone-forming osteoblasts. She is currently funded to investigate the therapeutic potential of embryonic stem cell-derived osteoprogenitors.