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Dr. Souba has a longstanding interest in the regulation of the altered amino acid transport that is characteristic of catabolic diseases such as injury, cancer, and infection. His research has focused predominately on the amino acid glutamine and how its interorgan flux is altered by stress states, and more specifically how plasma membrane transport is controlled during critical illness. The research group has looked extensively at the impact of glucocorticoids and cytokines on the regulation of carrier mediated glutamine transport. Other amino acids such as arginine have also been investigated.
A number of research models have been utilized including whole animal models, regional flux models, cultured cells, and membrane vesicles. The use of these techniques has led to important conclusions about how amino acid transport changes after a catabolic insult. As the genes that encode for the system N (glutamine) and system y+ (arginine) have now been cloned, the molecular regulation of these transporters has been is an important focus of the laboratory.
On a different note, Dr. Souba also has a longstanding interest in leadership at academic medical centers. He has written extensively on topics such as strategy, organizational change, mentoring and leadership philosophy. | 
