Indol-2-one intermediates: mechanistic evidence and synthetic utility. Total syntheses of (+/-)-flustramines A and C. Journal   Organic letters. Citation   Org Lett. 7(4):677-80 Publication date   2005 Feb 17 Authors   Fuchs JR Funk RL Investigators   Raymond Funk Grant agencies   National Institute of General Medical Sciences Grants   NIGMS GM 28553 Abstract   A variety of 3,3-disubstituted 2-indolinones have been prepared by treatment of 3-bromo-3-alkyl-2-indolinones with dienophiles/nucleophiles in the presence of cesium carbonate. Application of this general strategy has facilitated the total syntheses of the reverse prenylated marine natural products (+/-)-flustramine A and (+/-)-flustramine C. [Structure: see text]