Formal total synthesis of the cytotoxic marine ascidian alkaloid haouamine A.
Journal
Organic letters.
Citation
Org Lett
. 8(11):2309-12
Publication date
2006 May 25
Authors
Jeong JH
Weinreb SM
Grant agencies
National Cancer Institute
National Institute of General Medical Sciences
Grants
NCI CA-34303
NIGMS GM-32299
Abstract
[reaction: see text] Described is a convergent 13-step synthesis of a pentacyclic compound which has previously been transformed into haouamine A, therefore constituting a formal total synthesis of this unique marine alkaloid.