New unusual iridoids from the leaves of noni (Morinda citrifolia L.) show inhibitory effect on ultraviolet B-induced transcriptional activator protein-1 (AP-1) activity. Journal   Bioorganic & medicinal chemistry. Citation   Bioorg Med Chem. 11(12):2499-502 Publication date   2003 Jun 12 Authors   Sang S Liu G He K Zhu N Dong Z Zheng Q Rosen RT Ho CT Investigators   Guangming Liu MeSH headings   Iridoids Morinda Transcription Factor AP-1 MeSH qualifiers   isolation & purification pharmacology chemistry antagonists & inhibitors radiation effects Abstract   A novel iridoid dimer in whose structure the two iridoid units are connected by a rare ether group, together with two new unusual iridoids showing significant inhibition of UVB-induced Activator Protein-1 (AP-1) activity in cell cultures, have been isolated from the leaves of noni (Morinda citrifolia L.). Their structures were determined on the basis of detailed high-field 1D and 2D spectral analysis. Their inhibitory effect on UVB-induced transcriptional Activator Protein-1 (AP-1) activity are also discussed. Medline ID   22642603